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Cephalic phase of insulin secretion in response to a meal is unrelated to family history of type 2 diabetes
The pre-absorptive cephalic phase of insulin secretion is elicited during the first ten min of a meal and before glucose levels rise. Its importance for insulin release during the post-absorptive phase has been well documented in animals but its presence or importance in man has become increasingly...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348013/ https://www.ncbi.nlm.nih.gov/pubmed/28288176 http://dx.doi.org/10.1371/journal.pone.0173654 |
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author | Eliasson, Björn Rawshani, Araz Axelsen, Mette Hammarstedt, Ann Smith, Ulf |
author_facet | Eliasson, Björn Rawshani, Araz Axelsen, Mette Hammarstedt, Ann Smith, Ulf |
author_sort | Eliasson, Björn |
collection | PubMed |
description | The pre-absorptive cephalic phase of insulin secretion is elicited during the first ten min of a meal and before glucose levels rise. Its importance for insulin release during the post-absorptive phase has been well documented in animals but its presence or importance in man has become increasingly controversial. We here examined the presence of an early cephalic phase of insulin release in 31 well matched individuals without (n = 15) or with (n = 16) a known family history of type 2 diabetes (first-degree relatives; FDR). We also examined the potential differences in individuals with or without impaired fasting (IFG) and impaired glucose tolerance (IGT). We here demonstrate that a cephalic phase of insulin secretion was present in all individuals examined and without any differences between control persons and FDR or IFG/IGT. However, the overall importance of the cephalic phase is conjectural since it was unrelated to the subsequent post-absorptive insulin release or glucose tolerance. One of the best predictors of the incremental cephalic phase of insulin release was fasting insulin level and, thus, a relation to degree of insulin sensitivity is likely. In conclusion, an early pre-absorptive and cephalic phase of insulin release is robustly present in man. However, we could not document any relation to family history of Type 2 diabetes nor to the post-absorptive phase and, thus, confirm its importance for subsequent degree of insulin release or glucose tolerance. |
format | Online Article Text |
id | pubmed-5348013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53480132017-03-30 Cephalic phase of insulin secretion in response to a meal is unrelated to family history of type 2 diabetes Eliasson, Björn Rawshani, Araz Axelsen, Mette Hammarstedt, Ann Smith, Ulf PLoS One Research Article The pre-absorptive cephalic phase of insulin secretion is elicited during the first ten min of a meal and before glucose levels rise. Its importance for insulin release during the post-absorptive phase has been well documented in animals but its presence or importance in man has become increasingly controversial. We here examined the presence of an early cephalic phase of insulin release in 31 well matched individuals without (n = 15) or with (n = 16) a known family history of type 2 diabetes (first-degree relatives; FDR). We also examined the potential differences in individuals with or without impaired fasting (IFG) and impaired glucose tolerance (IGT). We here demonstrate that a cephalic phase of insulin secretion was present in all individuals examined and without any differences between control persons and FDR or IFG/IGT. However, the overall importance of the cephalic phase is conjectural since it was unrelated to the subsequent post-absorptive insulin release or glucose tolerance. One of the best predictors of the incremental cephalic phase of insulin release was fasting insulin level and, thus, a relation to degree of insulin sensitivity is likely. In conclusion, an early pre-absorptive and cephalic phase of insulin release is robustly present in man. However, we could not document any relation to family history of Type 2 diabetes nor to the post-absorptive phase and, thus, confirm its importance for subsequent degree of insulin release or glucose tolerance. Public Library of Science 2017-03-13 /pmc/articles/PMC5348013/ /pubmed/28288176 http://dx.doi.org/10.1371/journal.pone.0173654 Text en © 2017 Eliasson et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Eliasson, Björn Rawshani, Araz Axelsen, Mette Hammarstedt, Ann Smith, Ulf Cephalic phase of insulin secretion in response to a meal is unrelated to family history of type 2 diabetes |
title | Cephalic phase of insulin secretion in response to a meal is unrelated to family history of type 2 diabetes |
title_full | Cephalic phase of insulin secretion in response to a meal is unrelated to family history of type 2 diabetes |
title_fullStr | Cephalic phase of insulin secretion in response to a meal is unrelated to family history of type 2 diabetes |
title_full_unstemmed | Cephalic phase of insulin secretion in response to a meal is unrelated to family history of type 2 diabetes |
title_short | Cephalic phase of insulin secretion in response to a meal is unrelated to family history of type 2 diabetes |
title_sort | cephalic phase of insulin secretion in response to a meal is unrelated to family history of type 2 diabetes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348013/ https://www.ncbi.nlm.nih.gov/pubmed/28288176 http://dx.doi.org/10.1371/journal.pone.0173654 |
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