Safety and Efficacy of a Topical Sodium Channel Inhibitor (TV-45070) in Patients With Postherpetic Neuralgia (PHN): A Randomized, Controlled, Proof-of-Concept, Crossover Study, With a Subgroup Analysis of the Nav1.7 R1150W Genotype

OBJECTIVE: The objective was to evaluate the safety and efficacy of TV-45070 ointment, as a treatment for postherpetic neuralgia, and to explore the response in patients with the Nav1.7 R1150W gain-of-function polymorphism. MATERIALS AND METHODS: This was a randomized, placebo-controlled, 2-period,...

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Detalles Bibliográficos
Autores principales: Price, Nicola, Namdari, Rostam, Neville, Judith, Proctor, Katie J.W., Kaber, Samer, Vest, Jeffery, Fetell, Michael, Malamut, Richard, Sherrington, Robin P., Pimstone, Simon N., Goldberg, Yigal P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348105/
https://www.ncbi.nlm.nih.gov/pubmed/28266963
http://dx.doi.org/10.1097/AJP.0000000000000408

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