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Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era
Nonorgan-specific autoantibodies (AAbs) are used for diagnosing autoimmune diseases but can also be detected in other conditions. We carried out a cross-sectional study with the aim to screen HIV1-infected patients in the era of highly active antiretroviral therapy (HAART) for AAbs and to analyze th...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348164/ https://www.ncbi.nlm.nih.gov/pubmed/28272216 http://dx.doi.org/10.1097/MD.0000000000006230 |
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author | Iordache, Laura Bengoufa, Djaouida Taulera, Olivier Rami, Agathe Lascoux-Combe, Caroline Day, Nesrine Parrinello, Maguy Sellier, Pierre-Olivier Molina, Jean-Michel Mahr, Alfred |
author_facet | Iordache, Laura Bengoufa, Djaouida Taulera, Olivier Rami, Agathe Lascoux-Combe, Caroline Day, Nesrine Parrinello, Maguy Sellier, Pierre-Olivier Molina, Jean-Michel Mahr, Alfred |
author_sort | Iordache, Laura |
collection | PubMed |
description | Nonorgan-specific autoantibodies (AAbs) are used for diagnosing autoimmune diseases but can also be detected in other conditions. We carried out a cross-sectional study with the aim to screen HIV1-infected patients in the era of highly active antiretroviral therapy (HAART) for AAbs and to analyze the association of their presence with hypergammaglobulinemia and immunovirological status. Blood samples from HIV1-infected patients without major concomitant illnesses followed in 2 hospitals in Paris, France were tested for immunovirological status, serum immunoglobulin G (IgG) level, antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), anti-extractable nuclear antigens (anti-ENAs), anticardiolipin (aCL), anti-β2glycoprotein1 (anti-β2GP1), and antineutrophil cytoplasmic antibodies (ANCAs). Clinically relevant AAbs were defined as ANAs with titers ≥1:160, anti-dsDNA or anti-ENA antibodies; aCL or anti-β2GP1 antibodies with a level ≥40 U/ml; and ANCAs reacting with proteinase 3 or myeloperoxidase. We included 92 patients (mean age 47 years, men 55%, sub-Saharan African background 55%, HAART 85%, mean CD4 lymphocyte count 611/mm(3), viral load < 40 copies/mL 74%). At least 1 AAb was detected in 45% of patients, mostly ANAs (33%) and ANCAs (13%); 12% had ≥1 clinically relevant AAb. Above-normal IgG levels were found in 71% of patients. We found an inverse association between the presence of ≥1 AAb and CD4 lymphocyte count (P = 0.03) and between above-normal IgG levels and duration of virological control (P = 0.02) and non-sub-Saharan African background (P = 0.001). In sum, in HIV1-infected patients without any major concomitant illness in the HAART era, the prevalence of AAbs remains high but AAb patterns leading to high suspicion of autoimmune diseases are rather uncommon. AAb presence is associated with reduced CD4 lymphocyte count but not hypergammaglobulinemia. |
format | Online Article Text |
id | pubmed-5348164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-53481642017-03-22 Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era Iordache, Laura Bengoufa, Djaouida Taulera, Olivier Rami, Agathe Lascoux-Combe, Caroline Day, Nesrine Parrinello, Maguy Sellier, Pierre-Olivier Molina, Jean-Michel Mahr, Alfred Medicine (Baltimore) 4850 Nonorgan-specific autoantibodies (AAbs) are used for diagnosing autoimmune diseases but can also be detected in other conditions. We carried out a cross-sectional study with the aim to screen HIV1-infected patients in the era of highly active antiretroviral therapy (HAART) for AAbs and to analyze the association of their presence with hypergammaglobulinemia and immunovirological status. Blood samples from HIV1-infected patients without major concomitant illnesses followed in 2 hospitals in Paris, France were tested for immunovirological status, serum immunoglobulin G (IgG) level, antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), anti-extractable nuclear antigens (anti-ENAs), anticardiolipin (aCL), anti-β2glycoprotein1 (anti-β2GP1), and antineutrophil cytoplasmic antibodies (ANCAs). Clinically relevant AAbs were defined as ANAs with titers ≥1:160, anti-dsDNA or anti-ENA antibodies; aCL or anti-β2GP1 antibodies with a level ≥40 U/ml; and ANCAs reacting with proteinase 3 or myeloperoxidase. We included 92 patients (mean age 47 years, men 55%, sub-Saharan African background 55%, HAART 85%, mean CD4 lymphocyte count 611/mm(3), viral load < 40 copies/mL 74%). At least 1 AAb was detected in 45% of patients, mostly ANAs (33%) and ANCAs (13%); 12% had ≥1 clinically relevant AAb. Above-normal IgG levels were found in 71% of patients. We found an inverse association between the presence of ≥1 AAb and CD4 lymphocyte count (P = 0.03) and between above-normal IgG levels and duration of virological control (P = 0.02) and non-sub-Saharan African background (P = 0.001). In sum, in HIV1-infected patients without any major concomitant illness in the HAART era, the prevalence of AAbs remains high but AAb patterns leading to high suspicion of autoimmune diseases are rather uncommon. AAb presence is associated with reduced CD4 lymphocyte count but not hypergammaglobulinemia. Wolters Kluwer Health 2017-03-10 /pmc/articles/PMC5348164/ /pubmed/28272216 http://dx.doi.org/10.1097/MD.0000000000006230 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 4850 Iordache, Laura Bengoufa, Djaouida Taulera, Olivier Rami, Agathe Lascoux-Combe, Caroline Day, Nesrine Parrinello, Maguy Sellier, Pierre-Olivier Molina, Jean-Michel Mahr, Alfred Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era |
title | Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era |
title_full | Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era |
title_fullStr | Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era |
title_full_unstemmed | Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era |
title_short | Nonorgan-specific autoantibodies in HIV-infected patients in the HAART era |
title_sort | nonorgan-specific autoantibodies in hiv-infected patients in the haart era |
topic | 4850 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348164/ https://www.ncbi.nlm.nih.gov/pubmed/28272216 http://dx.doi.org/10.1097/MD.0000000000006230 |
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