Smad4 in T cells plays a protective role in the development of autoimmune Sjögren's syndrome in the nonobese diabetic mouse

We investigated the role of Smad4, a signaling molecule of the TGF-beta pathway, in T cells on the pathology of Sjögren's syndrome (SS) in nonobese diabetic (NOD) mice, an animal model of SS. T cell-specific Smad4-deleted (Smad4(fl/fl,CD4-Cre); Smad4 tKO) NOD mice had accelerated development of...

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Detalles Bibliográficos
Autores principales: Kim, Donghee, Kim, Jae Young, Jun, Hee-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348321/
https://www.ncbi.nlm.nih.gov/pubmed/27880731
http://dx.doi.org/10.18632/oncotarget.13437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348321/
https://www.ncbi.nlm.nih.gov/pubmed/27880731
http://dx.doi.org/10.18632/oncotarget.13437

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