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Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells

Acrolein (Acr) is a potent cytotoxic and DNA damaging agent which is ubiquitous in the environment and abundant in tobacco smoke. Acr is also an active cytotoxic metabolite of the anti-cancer drugs cyclophosphamide and ifosfamide. The mechanisms via which Acr exerts its anti-cancer activity and cyto...

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Detalles Bibliográficos
Autores principales:	Wang, Hsiang-tsui, Chen, Tzu-ying, Weng, Ching-wen, Yang, Chun-hsiang, Tang, Moon-shong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348333/ https://www.ncbi.nlm.nih.gov/pubmed/27741518 http://dx.doi.org/10.18632/oncotarget.12608

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