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Activation of PI3Kγ/Akt pathway increases cardiomyocyte HMGB1 expression in diabetic environment
BACKGROUND: The high mobility group box 1 (HMGB1) protein mediates the cardiomyocyte–cardiac fibroblast interaction that contributes to induction of myocardial fibrosis in diabetes mellitus (DM). In the present study, we aim to investigate the intracellular signaling pathway that leads to cardiomyoc...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348356/ https://www.ncbi.nlm.nih.gov/pubmed/27821807 http://dx.doi.org/10.18632/oncotarget.13096 |