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Enrichment of C5a-C5aR axis predicts poor postoperative prognosis of patients with clear cell renal cell carcinoma

Anaphylatoxin C5a and its receptor C5aR on cancer cells constitute a vital axis to cancer progression. In this study, we measured C5aR level by immunohistochemistry in the same cohort of our previous C5a research, and C5a-C5aR axis status was determined by synthesizing C5a and C5aR data. C5aR was an...

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Autores principales: Xi, Wei, Liu, Li, Wang, Jiajun, Xia, Yu, Bai, Qi, Xiong, Ying, Qu, Yang, Long, Qilai, Xu, Jiejie, Guo, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348365/
https://www.ncbi.nlm.nih.gov/pubmed/27821813
http://dx.doi.org/10.18632/oncotarget.13108
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author Xi, Wei
Liu, Li
Wang, Jiajun
Xia, Yu
Bai, Qi
Xiong, Ying
Qu, Yang
Long, Qilai
Xu, Jiejie
Guo, Jianming
author_facet Xi, Wei
Liu, Li
Wang, Jiajun
Xia, Yu
Bai, Qi
Xiong, Ying
Qu, Yang
Long, Qilai
Xu, Jiejie
Guo, Jianming
author_sort Xi, Wei
collection PubMed
description Anaphylatoxin C5a and its receptor C5aR on cancer cells constitute a vital axis to cancer progression. In this study, we measured C5aR level by immunohistochemistry in the same cohort of our previous C5a research, and C5a-C5aR axis status was determined by synthesizing C5a and C5aR data. C5aR was an adverse independent prognostic factor for ccRCC patients. Kaplan-Meier analyses revealed the unique position of both C5a and C5aR high population in postoperative survival, based on which patients were then shunted into C5a-C5aR enriched and non-enriched groups. Obviously, C5a-C5aR enriched patients significantly had a poorer overall survival (OS) and recurrence free survival (RFS) compared with non-enriched ones, and the independence of C5a-C5aR axis was verified by multivariable analyses (HR 2.118, P = 0.001 for OS, HR 1.715, P = 0.035 for RFS). Established nomograms based on our findings reflected much better predicting accuracy in contrast with most common used TNM and Fuhrman systems. Meanwhile, consistent with HR, C5a-C5aR axis in this study held its advantages over C5a and C5aR for OS prediction by c-index analyses, rather than RFS prediction.
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spelling pubmed-53483652017-03-31 Enrichment of C5a-C5aR axis predicts poor postoperative prognosis of patients with clear cell renal cell carcinoma Xi, Wei Liu, Li Wang, Jiajun Xia, Yu Bai, Qi Xiong, Ying Qu, Yang Long, Qilai Xu, Jiejie Guo, Jianming Oncotarget Research Paper Anaphylatoxin C5a and its receptor C5aR on cancer cells constitute a vital axis to cancer progression. In this study, we measured C5aR level by immunohistochemistry in the same cohort of our previous C5a research, and C5a-C5aR axis status was determined by synthesizing C5a and C5aR data. C5aR was an adverse independent prognostic factor for ccRCC patients. Kaplan-Meier analyses revealed the unique position of both C5a and C5aR high population in postoperative survival, based on which patients were then shunted into C5a-C5aR enriched and non-enriched groups. Obviously, C5a-C5aR enriched patients significantly had a poorer overall survival (OS) and recurrence free survival (RFS) compared with non-enriched ones, and the independence of C5a-C5aR axis was verified by multivariable analyses (HR 2.118, P = 0.001 for OS, HR 1.715, P = 0.035 for RFS). Established nomograms based on our findings reflected much better predicting accuracy in contrast with most common used TNM and Fuhrman systems. Meanwhile, consistent with HR, C5a-C5aR axis in this study held its advantages over C5a and C5aR for OS prediction by c-index analyses, rather than RFS prediction. Impact Journals LLC 2016-11-04 /pmc/articles/PMC5348365/ /pubmed/27821813 http://dx.doi.org/10.18632/oncotarget.13108 Text en Copyright: © 2016 Xi et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Xi, Wei
Liu, Li
Wang, Jiajun
Xia, Yu
Bai, Qi
Xiong, Ying
Qu, Yang
Long, Qilai
Xu, Jiejie
Guo, Jianming
Enrichment of C5a-C5aR axis predicts poor postoperative prognosis of patients with clear cell renal cell carcinoma
title Enrichment of C5a-C5aR axis predicts poor postoperative prognosis of patients with clear cell renal cell carcinoma
title_full Enrichment of C5a-C5aR axis predicts poor postoperative prognosis of patients with clear cell renal cell carcinoma
title_fullStr Enrichment of C5a-C5aR axis predicts poor postoperative prognosis of patients with clear cell renal cell carcinoma
title_full_unstemmed Enrichment of C5a-C5aR axis predicts poor postoperative prognosis of patients with clear cell renal cell carcinoma
title_short Enrichment of C5a-C5aR axis predicts poor postoperative prognosis of patients with clear cell renal cell carcinoma
title_sort enrichment of c5a-c5ar axis predicts poor postoperative prognosis of patients with clear cell renal cell carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348365/
https://www.ncbi.nlm.nih.gov/pubmed/27821813
http://dx.doi.org/10.18632/oncotarget.13108
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