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Everolimus (RAD001) sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1α and sphingosine kinase 1

Resistance to docetaxel is a key problem in current prostate cancer management. Sphingosine kinase 1 (SK1) and phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathways have been implicated in prostate cancer chemoresistance. Here we investigated whether their combined targe...

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Detalles Bibliográficos
Autores principales:	Alshaker, Heba, Wang, Qi, Kawano, Yoshiaki, Arafat, Tawfiq, Böhler, Torsten, Winkler, Mathias, Cooper, Colin, Pchejetski, Dmitri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348367/ https://www.ncbi.nlm.nih.gov/pubmed/27821815 http://dx.doi.org/10.18632/oncotarget.13115

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