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Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma
Orai3 channel has emerged as important player in malignant transformation. Indeed, its expression is increased in cancer and favors cell proliferation and survival by permitting calcium influx. In this study, Orai3 was overexpressed in lung adenocarcinoma as compared to their matched non-tumour samp...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348414/ https://www.ncbi.nlm.nih.gov/pubmed/27835593 http://dx.doi.org/10.18632/oncotarget.13149 |
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author | Benzerdjeb, Nazim Sevestre, Henri Ahidouch, Ahmed Ouadid-Ahidouch, Halima |
author_facet | Benzerdjeb, Nazim Sevestre, Henri Ahidouch, Ahmed Ouadid-Ahidouch, Halima |
author_sort | Benzerdjeb, Nazim |
collection | PubMed |
description | Orai3 channel has emerged as important player in malignant transformation. Indeed, its expression is increased in cancer and favors cell proliferation and survival by permitting calcium influx. In this study, Orai3 was overexpressed in lung adenocarcinoma as compared to their matched non-tumour samples and was associated with tumoural aggressiveness. Moreover, its expression was associated with estrogen receptor alpha (ERα) expression and visceral pleural invasion in multivariate analysis. Furthermore, both the overall survival (OS) median and the metastasis free survival (MFS) median of tumors with high Orai3 expression were lower than in low Orai3 expression regardless of cancer stage (35.01 months vs. 51.11 months for OS and 46.01 months vs. 62.04 months for MFS). In conclusion, Orai3 protein level constitutes an independent prognostic marker in lung adenocarcinoma, and a novel prognostic marker that could help selecting the patients with worst prognosis to be treated with adjuvant chemotherapy in resectable stage. |
format | Online Article Text |
id | pubmed-5348414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53484142017-03-31 Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma Benzerdjeb, Nazim Sevestre, Henri Ahidouch, Ahmed Ouadid-Ahidouch, Halima Oncotarget Research Paper Orai3 channel has emerged as important player in malignant transformation. Indeed, its expression is increased in cancer and favors cell proliferation and survival by permitting calcium influx. In this study, Orai3 was overexpressed in lung adenocarcinoma as compared to their matched non-tumour samples and was associated with tumoural aggressiveness. Moreover, its expression was associated with estrogen receptor alpha (ERα) expression and visceral pleural invasion in multivariate analysis. Furthermore, both the overall survival (OS) median and the metastasis free survival (MFS) median of tumors with high Orai3 expression were lower than in low Orai3 expression regardless of cancer stage (35.01 months vs. 51.11 months for OS and 46.01 months vs. 62.04 months for MFS). In conclusion, Orai3 protein level constitutes an independent prognostic marker in lung adenocarcinoma, and a novel prognostic marker that could help selecting the patients with worst prognosis to be treated with adjuvant chemotherapy in resectable stage. Impact Journals LLC 2016-11-07 /pmc/articles/PMC5348414/ /pubmed/27835593 http://dx.doi.org/10.18632/oncotarget.13149 Text en Copyright: © 2016 Benzerdjeb et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Benzerdjeb, Nazim Sevestre, Henri Ahidouch, Ahmed Ouadid-Ahidouch, Halima Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma |
title | Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma |
title_full | Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma |
title_fullStr | Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma |
title_full_unstemmed | Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma |
title_short | Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma |
title_sort | orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348414/ https://www.ncbi.nlm.nih.gov/pubmed/27835593 http://dx.doi.org/10.18632/oncotarget.13149 |
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