A functional variant rs4442975 modulating FOXA1-binding affinity does not influence the risk or progression of breast cancer in Chinese Han population

The DNA-binding protein FOXA1 has been shown to regulate nearly all estrogen receptor-chromatin interactions, thereby influencing target gene expression levels in breast cancer (BC) cells. Recently, the rs4442975 T-allele, which disrupts the recruitment of FOXA1 and interacts with the IGFBP5 promote...

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Detalles Bibliográficos
Autores principales: Zhang, Yi, Li, Yan, Jiang, Shaojie, Chen, Wei, Lou, Jiao, Ke, Juntao, Li, Jiaoyuan, Zhu, Ying, Gong, Yajie, Yang, Yang, Tian, Jianbo, Peng, Xiating, Zou, Danyi, Gong, Jing, Chang, Jiang, Miao, Xiaoping, Zhong, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348423/
https://www.ncbi.nlm.nih.gov/pubmed/27835577
http://dx.doi.org/10.18632/oncotarget.13168

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