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Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer
Previous studies have investigated the prognostic significance of B7 homolog 3 (B7-H3) in non-small cell lung cancer (NSCLC), however, the results remain controversial. This study was aimed to determine the correlation between B7-H3 and survival as well as clnicalpathological characteristics in NSCL...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348426/ https://www.ncbi.nlm.nih.gov/pubmed/27835582 http://dx.doi.org/10.18632/oncotarget.13177 |
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author | Wu, Shanshan Zhao, Xiangfei Wu, Sudong Du, Rui Zhu, Qi Fang, Henghu Zhang, Xinhong Zhang, Chunyang Zheng, Wei Yang, Jihua Feng, Huasong |
author_facet | Wu, Shanshan Zhao, Xiangfei Wu, Sudong Du, Rui Zhu, Qi Fang, Henghu Zhang, Xinhong Zhang, Chunyang Zheng, Wei Yang, Jihua Feng, Huasong |
author_sort | Wu, Shanshan |
collection | PubMed |
description | Previous studies have investigated the prognostic significance of B7 homolog 3 (B7-H3) in non-small cell lung cancer (NSCLC), however, the results remain controversial. This study was aimed to determine the correlation between B7-H3 and survival as well as clnicalpathological characteristics in NSCLC using meta-analysis. We searched the electronic databases of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) for relevant studies up to October 9, 2016. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were used to estimate the impact of B7-H3 on overall survival (OS). Combined odds ratios (ORs) and 95%CIs were utilized to evaluate the correlations between B7-H3 and clinicalpathological features. This meta-analysis finally included 7 studies with 864 patients. The results showed that B7-H3 had no significant association with OS (HR=0.88, 95%CI: 0.36-2.13, p=0.776). High B7-H3 expression was a significant indicator of lymph node metastasis (OR=3.92, 95%CI: 2.65-5.81, p<0.001), and advanced TNM stage (OR=3.53, 95%CI: 2.45-5.09, p<0.001). B7-H3 has the potential to serve as a marker of tumor aggressiveness and lymph node metastasis in NSCLC. However, due to several limitations, further large-scale studies are needed to validate our results. |
format | Online Article Text |
id | pubmed-5348426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53484262017-03-31 Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer Wu, Shanshan Zhao, Xiangfei Wu, Sudong Du, Rui Zhu, Qi Fang, Henghu Zhang, Xinhong Zhang, Chunyang Zheng, Wei Yang, Jihua Feng, Huasong Oncotarget Research Paper Previous studies have investigated the prognostic significance of B7 homolog 3 (B7-H3) in non-small cell lung cancer (NSCLC), however, the results remain controversial. This study was aimed to determine the correlation between B7-H3 and survival as well as clnicalpathological characteristics in NSCLC using meta-analysis. We searched the electronic databases of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) for relevant studies up to October 9, 2016. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were used to estimate the impact of B7-H3 on overall survival (OS). Combined odds ratios (ORs) and 95%CIs were utilized to evaluate the correlations between B7-H3 and clinicalpathological features. This meta-analysis finally included 7 studies with 864 patients. The results showed that B7-H3 had no significant association with OS (HR=0.88, 95%CI: 0.36-2.13, p=0.776). High B7-H3 expression was a significant indicator of lymph node metastasis (OR=3.92, 95%CI: 2.65-5.81, p<0.001), and advanced TNM stage (OR=3.53, 95%CI: 2.45-5.09, p<0.001). B7-H3 has the potential to serve as a marker of tumor aggressiveness and lymph node metastasis in NSCLC. However, due to several limitations, further large-scale studies are needed to validate our results. Impact Journals LLC 2016-11-07 /pmc/articles/PMC5348426/ /pubmed/27835582 http://dx.doi.org/10.18632/oncotarget.13177 Text en Copyright: © 2016 Wu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Wu, Shanshan Zhao, Xiangfei Wu, Sudong Du, Rui Zhu, Qi Fang, Henghu Zhang, Xinhong Zhang, Chunyang Zheng, Wei Yang, Jihua Feng, Huasong Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer |
title | Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer |
title_full | Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer |
title_fullStr | Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer |
title_full_unstemmed | Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer |
title_short | Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer |
title_sort | overexpression of b7-h3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348426/ https://www.ncbi.nlm.nih.gov/pubmed/27835582 http://dx.doi.org/10.18632/oncotarget.13177 |
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