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Accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features

PURPOSE: Accelerated whole breast irradiation (AWBI) and conventional whole breast irradiation (CWBI) were compared to determine whether AWBI is as effective as CWBI in patients with early breast cancer and adverse prognostic features. PATIENTS AND METHODS: We included 330 patients who underwent bre...

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Autores principales: Lee, Sea-Won, Shin, Kyung Hwan, Chie, Eui Kyu, Kim, Jin Ho, Im, Seock-Ah, Han, Wonshik, Noh, Dong-Young, Lim, Hyeon Woo, Kim, Tae Hyun, Lee, Keun Seok, Lee, Eun Sook, Sung, Soo Yoon, Kim, Kyubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348439/
https://www.ncbi.nlm.nih.gov/pubmed/27588485
http://dx.doi.org/10.18632/oncotarget.11702
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author Lee, Sea-Won
Shin, Kyung Hwan
Chie, Eui Kyu
Kim, Jin Ho
Im, Seock-Ah
Han, Wonshik
Noh, Dong-Young
Lim, Hyeon Woo
Kim, Tae Hyun
Lee, Keun Seok
Lee, Eun Sook
Sung, Soo Yoon
Kim, Kyubo
author_facet Lee, Sea-Won
Shin, Kyung Hwan
Chie, Eui Kyu
Kim, Jin Ho
Im, Seock-Ah
Han, Wonshik
Noh, Dong-Young
Lim, Hyeon Woo
Kim, Tae Hyun
Lee, Keun Seok
Lee, Eun Sook
Sung, Soo Yoon
Kim, Kyubo
author_sort Lee, Sea-Won
collection PubMed
description PURPOSE: Accelerated whole breast irradiation (AWBI) and conventional whole breast irradiation (CWBI) were compared to determine whether AWBI is as effective as CWBI in patients with early breast cancer and adverse prognostic features. PATIENTS AND METHODS: We included 330 patients who underwent breast-conserving surgery (BCS) and post-operative radiation therapy (RT) using AWBI for pT1-2 and pN0-1a breast cancer from 2007 to 2010. These patients were matched with 330 patients who received CWBI according to stage, age (±3 years), and the year of BCS. AWBI of 39 Gy and CWBI of 50.4 Gy were given in 13 and 28 fractions, respectively. RESULTS: Median follow-up time was 81.9 months. There were no statistically significant differences between the AWBI and CWBI groups in terms of age, stage, tumor grade, or molecular subtype. More patients with Ki-67 index ≥ 14% were present in the AWBI group (AWBI 47.0% vs. CWBI 10.3%; P<0.01). The 5-year ipsilateral breast tumor relapse (IBTR) rates for the AWBI and CWBI groups were 0.8% and 1.8%, respectively (P=0.54). High tumor grade was a statistically significant risk factor for IBTR (5-year IBTR rate: 2.9%; P=0.01). Ki-67 ≥ 14% was marginally related to IBTR (5-year IBTR rate: 2.2%; P=0.07). There were no statistically significant differences in the hazard ratios between the AWBI and CWBI groups according to any of the risk factors. There were no acute grade 3 toxicities in the AWBI group. There were no late grade 3 toxicities in either group. CONCLUSIONS: AWBI is comparable to CWBI in early breast cancer with adverse prognostic features.
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spelling pubmed-53484392017-03-31 Accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features Lee, Sea-Won Shin, Kyung Hwan Chie, Eui Kyu Kim, Jin Ho Im, Seock-Ah Han, Wonshik Noh, Dong-Young Lim, Hyeon Woo Kim, Tae Hyun Lee, Keun Seok Lee, Eun Sook Sung, Soo Yoon Kim, Kyubo Oncotarget Clinical Research Paper PURPOSE: Accelerated whole breast irradiation (AWBI) and conventional whole breast irradiation (CWBI) were compared to determine whether AWBI is as effective as CWBI in patients with early breast cancer and adverse prognostic features. PATIENTS AND METHODS: We included 330 patients who underwent breast-conserving surgery (BCS) and post-operative radiation therapy (RT) using AWBI for pT1-2 and pN0-1a breast cancer from 2007 to 2010. These patients were matched with 330 patients who received CWBI according to stage, age (±3 years), and the year of BCS. AWBI of 39 Gy and CWBI of 50.4 Gy were given in 13 and 28 fractions, respectively. RESULTS: Median follow-up time was 81.9 months. There were no statistically significant differences between the AWBI and CWBI groups in terms of age, stage, tumor grade, or molecular subtype. More patients with Ki-67 index ≥ 14% were present in the AWBI group (AWBI 47.0% vs. CWBI 10.3%; P<0.01). The 5-year ipsilateral breast tumor relapse (IBTR) rates for the AWBI and CWBI groups were 0.8% and 1.8%, respectively (P=0.54). High tumor grade was a statistically significant risk factor for IBTR (5-year IBTR rate: 2.9%; P=0.01). Ki-67 ≥ 14% was marginally related to IBTR (5-year IBTR rate: 2.2%; P=0.07). There were no statistically significant differences in the hazard ratios between the AWBI and CWBI groups according to any of the risk factors. There were no acute grade 3 toxicities in the AWBI group. There were no late grade 3 toxicities in either group. CONCLUSIONS: AWBI is comparable to CWBI in early breast cancer with adverse prognostic features. Impact Journals LLC 2016-08-30 /pmc/articles/PMC5348439/ /pubmed/27588485 http://dx.doi.org/10.18632/oncotarget.11702 Text en Copyright: © 2016 Lee et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Clinical Research Paper
Lee, Sea-Won
Shin, Kyung Hwan
Chie, Eui Kyu
Kim, Jin Ho
Im, Seock-Ah
Han, Wonshik
Noh, Dong-Young
Lim, Hyeon Woo
Kim, Tae Hyun
Lee, Keun Seok
Lee, Eun Sook
Sung, Soo Yoon
Kim, Kyubo
Accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features
title Accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features
title_full Accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features
title_fullStr Accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features
title_full_unstemmed Accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features
title_short Accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features
title_sort accelerated whole breast irradiation in early breast cancer patients with adverse prognostic features
topic Clinical Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348439/
https://www.ncbi.nlm.nih.gov/pubmed/27588485
http://dx.doi.org/10.18632/oncotarget.11702
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