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Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles

We present a case of multiple primary lung cancer(MPLC) displaying heterogeneous EGFR and PTEN molecular profiles. Considering the physical condition of patients, the patient underwent surgical resection of the right lung lesion displaying gefitinib-insensitive and continued gefitinib treatment for...

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Detalles Bibliográficos
Autores principales: Zhu, Zhouyu, Yu, Tao, Chai, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348444/
https://www.ncbi.nlm.nih.gov/pubmed/27823967
http://dx.doi.org/10.18632/oncotarget.13046
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author Zhu, Zhouyu
Yu, Tao
Chai, Ying
author_facet Zhu, Zhouyu
Yu, Tao
Chai, Ying
author_sort Zhu, Zhouyu
collection PubMed
description We present a case of multiple primary lung cancer(MPLC) displaying heterogeneous EGFR and PTEN molecular profiles. Considering the physical condition of patients, the patient underwent surgical resection of the right lung lesion displaying gefitinib-insensitive and continued gefitinib treatment for the gefitinib-sensitive lesions in the left lung. As far as we know, this is the first report documenting a case of an integrated therapy strategy using surgical resection with gefitinib treatment for MPLC displaying different EGFR and PTEN molecular profiles. The patient has been in progression free survival up to now. Our experience could provide a treatment strategy for patients with similar disease.
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spelling pubmed-53484442017-03-31 Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles Zhu, Zhouyu Yu, Tao Chai, Ying Oncotarget Case Report We present a case of multiple primary lung cancer(MPLC) displaying heterogeneous EGFR and PTEN molecular profiles. Considering the physical condition of patients, the patient underwent surgical resection of the right lung lesion displaying gefitinib-insensitive and continued gefitinib treatment for the gefitinib-sensitive lesions in the left lung. As far as we know, this is the first report documenting a case of an integrated therapy strategy using surgical resection with gefitinib treatment for MPLC displaying different EGFR and PTEN molecular profiles. The patient has been in progression free survival up to now. Our experience could provide a treatment strategy for patients with similar disease. Impact Journals LLC 2016-11-03 /pmc/articles/PMC5348444/ /pubmed/27823967 http://dx.doi.org/10.18632/oncotarget.13046 Text en Copyright: © 2016 Zhu et al. https://creativecommons.org/licenses/by/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Case Report
Zhu, Zhouyu
Yu, Tao
Chai, Ying
Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles
title Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles
title_full Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles
title_fullStr Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles
title_full_unstemmed Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles
title_short Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles
title_sort multiple primary lung cancer displaying different egfr and pten molecular profiles
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348444/
https://www.ncbi.nlm.nih.gov/pubmed/27823967
http://dx.doi.org/10.18632/oncotarget.13046
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