The Features of Colorectal Tumors in a Patient with Li-Fraumeni Syndrome

A young woman with Li-Fraumeni syndrome (LFS) was referred to our hospital. On examination, multiple flat neoplasms were detected in addition to semi-pedunculated polyps. Restorative proctocolectomy was performed; one submucosal invasive cancer, two mucosal cancers, and several adenomas with high-gr...

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Autores principales: Yoshida, Tsukasa, Tajika, Masahiro, Tanaka, Tsutomu, Ishihara, Makoto, Hirayama, Yutaka, Mizuno, Nobumasa, Hara, Kazuo, Hijioka, Susumu, Imaoka, Hiroshi, Hieda, Nobuhiro, Okuno, Nozomi, Kinoshita, Takashi, Bhatia, Vikram, Shimizu, Yasuhiro, Yatabe, Yasushi, Yamao, Kenji, Niwa, Yasumasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348453/
https://www.ncbi.nlm.nih.gov/pubmed/28154273
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author Yoshida, Tsukasa
Tajika, Masahiro
Tanaka, Tsutomu
Ishihara, Makoto
Hirayama, Yutaka
Mizuno, Nobumasa
Hara, Kazuo
Hijioka, Susumu
Imaoka, Hiroshi
Hieda, Nobuhiro
Okuno, Nozomi
Kinoshita, Takashi
Bhatia, Vikram
Shimizu, Yasuhiro
Yatabe, Yasushi
Yamao, Kenji
Niwa, Yasumasa
author_facet Yoshida, Tsukasa
Tajika, Masahiro
Tanaka, Tsutomu
Ishihara, Makoto
Hirayama, Yutaka
Mizuno, Nobumasa
Hara, Kazuo
Hijioka, Susumu
Imaoka, Hiroshi
Hieda, Nobuhiro
Okuno, Nozomi
Kinoshita, Takashi
Bhatia, Vikram
Shimizu, Yasuhiro
Yatabe, Yasushi
Yamao, Kenji
Niwa, Yasumasa
author_sort Yoshida, Tsukasa
collection PubMed
description A young woman with Li-Fraumeni syndrome (LFS) was referred to our hospital. On examination, multiple flat neoplasms were detected in addition to semi-pedunculated polyps. Restorative proctocolectomy was performed; one submucosal invasive cancer, two mucosal cancers, and several adenomas with high-grade dysplasia were detected. On immunohistochemical staining with p53, every part of all neoplasms, even the small adenomas, showed strong positive staining. Multiple flat neoplasms may be characteristic of patients with LFS and may have a much higher risk of rapid progression to invasive carcinomas than sporadic neoplasms. Thus, careful and frequent colonoscopy surveillance may be needed for patients with LFS.
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spelling pubmed-53484532017-03-24 The Features of Colorectal Tumors in a Patient with Li-Fraumeni Syndrome Yoshida, Tsukasa Tajika, Masahiro Tanaka, Tsutomu Ishihara, Makoto Hirayama, Yutaka Mizuno, Nobumasa Hara, Kazuo Hijioka, Susumu Imaoka, Hiroshi Hieda, Nobuhiro Okuno, Nozomi Kinoshita, Takashi Bhatia, Vikram Shimizu, Yasuhiro Yatabe, Yasushi Yamao, Kenji Niwa, Yasumasa Intern Med Case Report A young woman with Li-Fraumeni syndrome (LFS) was referred to our hospital. On examination, multiple flat neoplasms were detected in addition to semi-pedunculated polyps. Restorative proctocolectomy was performed; one submucosal invasive cancer, two mucosal cancers, and several adenomas with high-grade dysplasia were detected. On immunohistochemical staining with p53, every part of all neoplasms, even the small adenomas, showed strong positive staining. Multiple flat neoplasms may be characteristic of patients with LFS and may have a much higher risk of rapid progression to invasive carcinomas than sporadic neoplasms. Thus, careful and frequent colonoscopy surveillance may be needed for patients with LFS. The Japanese Society of Internal Medicine 2017-02-01 /pmc/articles/PMC5348453/ /pubmed/28154273 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yoshida, Tsukasa
Tajika, Masahiro
Tanaka, Tsutomu
Ishihara, Makoto
Hirayama, Yutaka
Mizuno, Nobumasa
Hara, Kazuo
Hijioka, Susumu
Imaoka, Hiroshi
Hieda, Nobuhiro
Okuno, Nozomi
Kinoshita, Takashi
Bhatia, Vikram
Shimizu, Yasuhiro
Yatabe, Yasushi
Yamao, Kenji
Niwa, Yasumasa
The Features of Colorectal Tumors in a Patient with Li-Fraumeni Syndrome
title The Features of Colorectal Tumors in a Patient with Li-Fraumeni Syndrome
title_full The Features of Colorectal Tumors in a Patient with Li-Fraumeni Syndrome
title_fullStr The Features of Colorectal Tumors in a Patient with Li-Fraumeni Syndrome
title_full_unstemmed The Features of Colorectal Tumors in a Patient with Li-Fraumeni Syndrome
title_short The Features of Colorectal Tumors in a Patient with Li-Fraumeni Syndrome
title_sort features of colorectal tumors in a patient with li-fraumeni syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348453/
https://www.ncbi.nlm.nih.gov/pubmed/28154273
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