Aspirin and risk of multiple myeloma in adults: A systematic review and meta-analysis

Multiple myeloma is a relatively uncommon plasma cell malignancy. Preclinical and clinical studies have suggested that aspirin might modify the risk of multiple myeloma. We performed a systematic review and meta-analysis of studies to examine the association between regular aspirin use and risk of m...

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Detalles Bibliográficos
Autores principales: Lee, Shing Fung, Ng, Ting Ying, Wong, Frank Chi Sing, Tung, Stewart Yuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348598/
https://www.ncbi.nlm.nih.gov/pubmed/28331798
http://dx.doi.org/10.1016/j.lrr.2017.02.002
Descripción
Sumario:Multiple myeloma is a relatively uncommon plasma cell malignancy. Preclinical and clinical studies have suggested that aspirin might modify the risk of multiple myeloma. We performed a systematic review and meta-analysis of studies to examine the association between regular aspirin use and risk of multiple myeloma. Five observational studies including 332,660 adults were evaluated. The pooled estimate had a hazard ratio of 0.90 (95% confidence interval =0.58−1.39; P=0.638). Odds ratios from the two case-control studies were similar. The findings demonstrated that there was no significant association between aspirin use and the risk of multiple myeloma.

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