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The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design

The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics analytic tools and access to depositories of curated data relevant to immune reactions and specific pathogens. The Immune Epitope Database and Analysis Resource (IEDB) was indeed created to assist biomedical r...

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Autores principales: Fleri, Ward, Paul, Sinu, Dhanda, Sandeep Kumar, Mahajan, Swapnil, Xu, Xiaojun, Peters, Bjoern, Sette, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348633/
https://www.ncbi.nlm.nih.gov/pubmed/28352270
http://dx.doi.org/10.3389/fimmu.2017.00278
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author Fleri, Ward
Paul, Sinu
Dhanda, Sandeep Kumar
Mahajan, Swapnil
Xu, Xiaojun
Peters, Bjoern
Sette, Alessandro
author_facet Fleri, Ward
Paul, Sinu
Dhanda, Sandeep Kumar
Mahajan, Swapnil
Xu, Xiaojun
Peters, Bjoern
Sette, Alessandro
author_sort Fleri, Ward
collection PubMed
description The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics analytic tools and access to depositories of curated data relevant to immune reactions and specific pathogens. The Immune Epitope Database and Analysis Resource (IEDB) was indeed created to assist biomedical researchers in the development of new vaccines, diagnostics, and therapeutics. The Analysis Resource is freely available to all researchers and provides access to a variety of epitope analysis and prediction tools. The tools include validated and benchmarked methods to predict MHC class I and class II binding. The predictions from these tools can be combined with tools predicting antigen processing, TCR recognition, and B cell epitope prediction. In addition, the resource contains a variety of secondary analysis tools that allow the researcher to calculate epitope conservation, population coverage, and other relevant analytic variables. The researcher involved in vaccine design and epitope discovery will also be interested in accessing experimental published data, relevant to the specific indication of interest. The database component of the IEDB contains a vast amount of experimentally derived epitope data that can be queried through a flexible user interface. The IEDB is linked to other pathogen-specific and immunological database resources.
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spelling pubmed-53486332017-03-28 The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design Fleri, Ward Paul, Sinu Dhanda, Sandeep Kumar Mahajan, Swapnil Xu, Xiaojun Peters, Bjoern Sette, Alessandro Front Immunol Immunology The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics analytic tools and access to depositories of curated data relevant to immune reactions and specific pathogens. The Immune Epitope Database and Analysis Resource (IEDB) was indeed created to assist biomedical researchers in the development of new vaccines, diagnostics, and therapeutics. The Analysis Resource is freely available to all researchers and provides access to a variety of epitope analysis and prediction tools. The tools include validated and benchmarked methods to predict MHC class I and class II binding. The predictions from these tools can be combined with tools predicting antigen processing, TCR recognition, and B cell epitope prediction. In addition, the resource contains a variety of secondary analysis tools that allow the researcher to calculate epitope conservation, population coverage, and other relevant analytic variables. The researcher involved in vaccine design and epitope discovery will also be interested in accessing experimental published data, relevant to the specific indication of interest. The database component of the IEDB contains a vast amount of experimentally derived epitope data that can be queried through a flexible user interface. The IEDB is linked to other pathogen-specific and immunological database resources. Frontiers Media S.A. 2017-03-14 /pmc/articles/PMC5348633/ /pubmed/28352270 http://dx.doi.org/10.3389/fimmu.2017.00278 Text en Copyright © 2017 Fleri, Paul, Dhanda, Mahajan, Xu, Peters and Sette. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Fleri, Ward
Paul, Sinu
Dhanda, Sandeep Kumar
Mahajan, Swapnil
Xu, Xiaojun
Peters, Bjoern
Sette, Alessandro
The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design
title The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design
title_full The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design
title_fullStr The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design
title_full_unstemmed The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design
title_short The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design
title_sort immune epitope database and analysis resource in epitope discovery and synthetic vaccine design
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348633/
https://www.ncbi.nlm.nih.gov/pubmed/28352270
http://dx.doi.org/10.3389/fimmu.2017.00278
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