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Role and mechanism of action of leucine-rich repeat kinase 1 in bone

Leucine-rich repeat kinase 1 (LRRK1) plays a critical role in regulating cytoskeletal organization, osteoclast activity, and bone resorption with little effect on bone formation parameters. Deficiency of Lrrk1 in mice causes a severe osteopetrosis in the metaphysis of the long bones and vertebrae bo...

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Detalles Bibliográficos
Autores principales:	Xing, Weirong R, Goodluck, Helen, Zeng, Canjun, Mohan, Subburaman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348726/ https://www.ncbi.nlm.nih.gov/pubmed/28326224 http://dx.doi.org/10.1038/boneres.2017.3

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