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Deep sequencing of HPV E6/E7 genes reveals loss of genotypic diversity and gain of clonal dominance in high-grade intraepithelial lesions of the cervix

BACKGROUND: Human papillomavirus (HPV) is the carcinogen of almost all invasive cervical cancer and a major cause of oral and other anogenital malignancies. HPV genotyping by dideoxy (Sanger) sequencing is currently the reference method of choice for clinical diagnostics. However, for samples with m...

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Detalles Bibliográficos
Autores principales:	Shen-Gunther, Jane, Wang, Yufeng, Lai, Zhao, Poage, Graham M., Perez, Luis, Huang, Tim H. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348809/ https://www.ncbi.nlm.nih.gov/pubmed/28288568 http://dx.doi.org/10.1186/s12864-017-3612-y

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