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Fatigue and sleepiness determine respiratory quality of life among veterans evaluated for sleep apnea

BACKGROUND: In those with symptoms indicative of obstructive sleep apnea (OSA), respiratory-specific health-related quality of life (HRQL) may be an important patient-centered outcome. The aim of this study was to assess the associations between sleepiness, fatigue, and impaired general and respirat...

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Autores principales: Vinnikov, Denis, Blanc, Paul D., Alilin, Alaena, Zutler, Moshe, Holty, Jon-Erik C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348814/
https://www.ncbi.nlm.nih.gov/pubmed/28288646
http://dx.doi.org/10.1186/s12955-017-0624-x
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author Vinnikov, Denis
Blanc, Paul D.
Alilin, Alaena
Zutler, Moshe
Holty, Jon-Erik C.
author_facet Vinnikov, Denis
Blanc, Paul D.
Alilin, Alaena
Zutler, Moshe
Holty, Jon-Erik C.
author_sort Vinnikov, Denis
collection PubMed
description BACKGROUND: In those with symptoms indicative of obstructive sleep apnea (OSA), respiratory-specific health-related quality of life (HRQL) may be an important patient-centered outcome. The aim of this study was to assess the associations between sleepiness, fatigue, and impaired general and respiratory-specific HRQL among persons with suspected OSA. METHODS: We evaluated military veterans consecutively referred for suspected OSA with sleep studies yielding apnea-hypopnea index (AHI) values. They also completed the sleepiness (Epworth Sleepiness Scale [ESS]), and fatigue (Fatigue Severity Scale [FSS]) questionnaires, as well as two HRQL instruments (the generic Short-Form SF-12v2 yielding the Physical Component Scale [PCS] and the respiratory-specific Airways Questionnaire [AQ]-20R). Multiple linear regression tested the associations between ESS and FSS (standardized as Z scores for scaling comparability) with AQ-20R, accounting for AHI, SF-12v2-PCS and comorbid respiratory conditions other than OSA. RESULTS: We studied 1578 veterans (median age 61.1 [IQR 16.8] years; 93.9% males). Of these, 823 (52%) met AHI criteria for moderate to severe OSA (AHI ≥15/h). The majority reported excessive daytime sleepiness (53%; median ESS 11 [IQR 9]) or fatigue (61%; median FSS 42 [IQR 23]). The median AQ-20R was 4 [IQR 1–8]. Controlling for AHI, SF-12v2-PCS, respiratory co-morbid conditions, body mass index, and demographics, both ESS and FSS were significantly associated with poorer AQ-20R: for each; ESS, 1.6 points (95% CI 1.4–1.9), and for FSS, 2.5 points (95% CI, 2.3–2.7). CONCLUSIONS: Greater daytime sleepiness and fatigue are associated with poorer respiratory-specific HRQL, over and above the effects of OSA, respiratory comorbidity, and generic physical HRQL.
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spelling pubmed-53488142017-03-14 Fatigue and sleepiness determine respiratory quality of life among veterans evaluated for sleep apnea Vinnikov, Denis Blanc, Paul D. Alilin, Alaena Zutler, Moshe Holty, Jon-Erik C. Health Qual Life Outcomes Research BACKGROUND: In those with symptoms indicative of obstructive sleep apnea (OSA), respiratory-specific health-related quality of life (HRQL) may be an important patient-centered outcome. The aim of this study was to assess the associations between sleepiness, fatigue, and impaired general and respiratory-specific HRQL among persons with suspected OSA. METHODS: We evaluated military veterans consecutively referred for suspected OSA with sleep studies yielding apnea-hypopnea index (AHI) values. They also completed the sleepiness (Epworth Sleepiness Scale [ESS]), and fatigue (Fatigue Severity Scale [FSS]) questionnaires, as well as two HRQL instruments (the generic Short-Form SF-12v2 yielding the Physical Component Scale [PCS] and the respiratory-specific Airways Questionnaire [AQ]-20R). Multiple linear regression tested the associations between ESS and FSS (standardized as Z scores for scaling comparability) with AQ-20R, accounting for AHI, SF-12v2-PCS and comorbid respiratory conditions other than OSA. RESULTS: We studied 1578 veterans (median age 61.1 [IQR 16.8] years; 93.9% males). Of these, 823 (52%) met AHI criteria for moderate to severe OSA (AHI ≥15/h). The majority reported excessive daytime sleepiness (53%; median ESS 11 [IQR 9]) or fatigue (61%; median FSS 42 [IQR 23]). The median AQ-20R was 4 [IQR 1–8]. Controlling for AHI, SF-12v2-PCS, respiratory co-morbid conditions, body mass index, and demographics, both ESS and FSS were significantly associated with poorer AQ-20R: for each; ESS, 1.6 points (95% CI 1.4–1.9), and for FSS, 2.5 points (95% CI, 2.3–2.7). CONCLUSIONS: Greater daytime sleepiness and fatigue are associated with poorer respiratory-specific HRQL, over and above the effects of OSA, respiratory comorbidity, and generic physical HRQL. BioMed Central 2017-03-14 /pmc/articles/PMC5348814/ /pubmed/28288646 http://dx.doi.org/10.1186/s12955-017-0624-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Vinnikov, Denis
Blanc, Paul D.
Alilin, Alaena
Zutler, Moshe
Holty, Jon-Erik C.
Fatigue and sleepiness determine respiratory quality of life among veterans evaluated for sleep apnea
title Fatigue and sleepiness determine respiratory quality of life among veterans evaluated for sleep apnea
title_full Fatigue and sleepiness determine respiratory quality of life among veterans evaluated for sleep apnea
title_fullStr Fatigue and sleepiness determine respiratory quality of life among veterans evaluated for sleep apnea
title_full_unstemmed Fatigue and sleepiness determine respiratory quality of life among veterans evaluated for sleep apnea
title_short Fatigue and sleepiness determine respiratory quality of life among veterans evaluated for sleep apnea
title_sort fatigue and sleepiness determine respiratory quality of life among veterans evaluated for sleep apnea
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348814/
https://www.ncbi.nlm.nih.gov/pubmed/28288646
http://dx.doi.org/10.1186/s12955-017-0624-x
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