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Protecting impact of Jaft against carbendazim induced biochemical changes in male Wistar rats

Introduction: Pesticides are a critical tool for crop protection and control of different pests and insects. The present research conducted to evaluate the protective role of Jaft extract against oxidative pressure, biochemical variations because of limited time giveaway to carbendazim in Wistar mic...

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Autores principales: Mirzaei, A, Sepehri, S, Sadeghi, H, Alamdari, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348936/
https://www.ncbi.nlm.nih.gov/pubmed/28316673
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author Mirzaei, A
Sepehri, S
Sadeghi, H
Alamdari, A
author_facet Mirzaei, A
Sepehri, S
Sadeghi, H
Alamdari, A
author_sort Mirzaei, A
collection PubMed
description Introduction: Pesticides are a critical tool for crop protection and control of different pests and insects. The present research conducted to evaluate the protective role of Jaft extract against oxidative pressure, biochemical variations because of limited time giveaway to carbendazim in Wistar mice males. Fresh fruits of quercus brantii were dried and the internal layer (Jaft) was collected for a hydroalcoholic extract by a maceration method at normal ambient condition. For the experimental study, twenty-four adult male rats (Wistar albino rats weighing 150-200 g) were randomized into 3 teams out of eight. Team I subserved like a vehicle treated group, received corn oil additionally to their food, while the animals in the second team got 0.1 ml carbendazim (50mg/ kg in corn oil) via oral path for nine days. Rats in group III received Jaft (500 mg/ kg orally + in carbendazim for 9 days. Blood samples were obtained by heart puncture to determine alkaline phosphatase (ALP), blood urea nitrogen (BUN), creatinine, alanine (ALT) and aspartate aminotransferases (AST); by using auto-analyzer in serum.Kidneys and liver separated from rats and provided for series of biochemical parameters homogenization like GSH and MDA stages. Result: The serum content of AST, ALT, ALP, BUN and creatinine were significantly elevated by in carbendazim treatment (group II) compared to the negative group (p<0.01).The liver enzymes operations, creatinine and BUN were significantly reduced in rats (p<0.05) when Jaft was received in a short period of time (group III). Hepatic and GSH and renal MDA stages in group (II) were clearly (p<0.05) enhanced and decreased consequently. The GSH and MDA stages content were significantly normalized in mice (p<0.05) when Jaft was received by group III. Conclusions: According to the present data, Jaft can neutralize carbendazim contain pressure of oxidative and recover the abnormal pathological injuries in Wistar mice males.
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spelling pubmed-53489362017-03-17 Protecting impact of Jaft against carbendazim induced biochemical changes in male Wistar rats Mirzaei, A Sepehri, S Sadeghi, H Alamdari, A J Med Life Original Articles Introduction: Pesticides are a critical tool for crop protection and control of different pests and insects. The present research conducted to evaluate the protective role of Jaft extract against oxidative pressure, biochemical variations because of limited time giveaway to carbendazim in Wistar mice males. Fresh fruits of quercus brantii were dried and the internal layer (Jaft) was collected for a hydroalcoholic extract by a maceration method at normal ambient condition. For the experimental study, twenty-four adult male rats (Wistar albino rats weighing 150-200 g) were randomized into 3 teams out of eight. Team I subserved like a vehicle treated group, received corn oil additionally to their food, while the animals in the second team got 0.1 ml carbendazim (50mg/ kg in corn oil) via oral path for nine days. Rats in group III received Jaft (500 mg/ kg orally + in carbendazim for 9 days. Blood samples were obtained by heart puncture to determine alkaline phosphatase (ALP), blood urea nitrogen (BUN), creatinine, alanine (ALT) and aspartate aminotransferases (AST); by using auto-analyzer in serum.Kidneys and liver separated from rats and provided for series of biochemical parameters homogenization like GSH and MDA stages. Result: The serum content of AST, ALT, ALP, BUN and creatinine were significantly elevated by in carbendazim treatment (group II) compared to the negative group (p<0.01).The liver enzymes operations, creatinine and BUN were significantly reduced in rats (p<0.05) when Jaft was received in a short period of time (group III). Hepatic and GSH and renal MDA stages in group (II) were clearly (p<0.05) enhanced and decreased consequently. The GSH and MDA stages content were significantly normalized in mice (p<0.05) when Jaft was received by group III. Conclusions: According to the present data, Jaft can neutralize carbendazim contain pressure of oxidative and recover the abnormal pathological injuries in Wistar mice males. Carol Davila University Press 2015 /pmc/articles/PMC5348936/ /pubmed/28316673 Text en ©Carol Davila University Press http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Mirzaei, A
Sepehri, S
Sadeghi, H
Alamdari, A
Protecting impact of Jaft against carbendazim induced biochemical changes in male Wistar rats
title Protecting impact of Jaft against carbendazim induced biochemical changes in male Wistar rats
title_full Protecting impact of Jaft against carbendazim induced biochemical changes in male Wistar rats
title_fullStr Protecting impact of Jaft against carbendazim induced biochemical changes in male Wistar rats
title_full_unstemmed Protecting impact of Jaft against carbendazim induced biochemical changes in male Wistar rats
title_short Protecting impact of Jaft against carbendazim induced biochemical changes in male Wistar rats
title_sort protecting impact of jaft against carbendazim induced biochemical changes in male wistar rats
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348936/
https://www.ncbi.nlm.nih.gov/pubmed/28316673
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