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Physiology, phylogeny, and LUCA

Genomes record their own history. But if we want to look all the way back to life's beginnings some 4 billion years ago, the record of microbial evolution that is preserved in prokaryotic genomes is not easy to read. Microbiology has a lot in common with geology in that regard. Geologists know...

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Autores principales: Martin, William F., Weiss, Madeline C., Neukirchen, Sinje, Nelson-Sathi, Shijulal, Sousa, Filipa L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348977/
https://www.ncbi.nlm.nih.gov/pubmed/28357330
http://dx.doi.org/10.15698/mic2016.12.545
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author Martin, William F.
Weiss, Madeline C.
Neukirchen, Sinje
Nelson-Sathi, Shijulal
Sousa, Filipa L.
author_facet Martin, William F.
Weiss, Madeline C.
Neukirchen, Sinje
Nelson-Sathi, Shijulal
Sousa, Filipa L.
author_sort Martin, William F.
collection PubMed
description Genomes record their own history. But if we want to look all the way back to life's beginnings some 4 billion years ago, the record of microbial evolution that is preserved in prokaryotic genomes is not easy to read. Microbiology has a lot in common with geology in that regard. Geologists know that plate tectonics and erosion have erased much of the geological record, with ancient rocks being truly rare. The same is true of microbes. Lateral gene transfer (LGT) and sequence divergence have erased much of the evolutionary record that was once written in genomes, and it is not obvious which genes among sequenced genomes are genuinely ancient. Which genes trace to the last universal ancestor, LUCA? The classical approach has been to look for genes that are universally distributed. Another approach is to make all trees for all genes, and sift out the trees where signals have been overwritten by LGT. What is left ought to be ancient. If we do that, what do we find?
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spelling pubmed-53489772017-03-29 Physiology, phylogeny, and LUCA Martin, William F. Weiss, Madeline C. Neukirchen, Sinje Nelson-Sathi, Shijulal Sousa, Filipa L. Microb Cell Microbiology Genomes record their own history. But if we want to look all the way back to life's beginnings some 4 billion years ago, the record of microbial evolution that is preserved in prokaryotic genomes is not easy to read. Microbiology has a lot in common with geology in that regard. Geologists know that plate tectonics and erosion have erased much of the geological record, with ancient rocks being truly rare. The same is true of microbes. Lateral gene transfer (LGT) and sequence divergence have erased much of the evolutionary record that was once written in genomes, and it is not obvious which genes among sequenced genomes are genuinely ancient. Which genes trace to the last universal ancestor, LUCA? The classical approach has been to look for genes that are universally distributed. Another approach is to make all trees for all genes, and sift out the trees where signals have been overwritten by LGT. What is left ought to be ancient. If we do that, what do we find? Shared Science Publishers OG 2016-11-25 /pmc/articles/PMC5348977/ /pubmed/28357330 http://dx.doi.org/10.15698/mic2016.12.545 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Microbiology
Martin, William F.
Weiss, Madeline C.
Neukirchen, Sinje
Nelson-Sathi, Shijulal
Sousa, Filipa L.
Physiology, phylogeny, and LUCA
title Physiology, phylogeny, and LUCA
title_full Physiology, phylogeny, and LUCA
title_fullStr Physiology, phylogeny, and LUCA
title_full_unstemmed Physiology, phylogeny, and LUCA
title_short Physiology, phylogeny, and LUCA
title_sort physiology, phylogeny, and luca
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348977/
https://www.ncbi.nlm.nih.gov/pubmed/28357330
http://dx.doi.org/10.15698/mic2016.12.545
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