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Autophagy: machinery and regulation

Macroautophagy/autophagy is an evolutionarily conserved cellular degradation process that targets cytoplasmic materials including cytosol, macromolecules and unwanted organelles. The discovery and analysis of autophagy-related (Atg) proteins have unveiled much of the machinery of autophagosome forma...

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Detalles Bibliográficos
Autores principales: Yin, Zhangyuan, Pascual, Clarence, Klionsky, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348978/
https://www.ncbi.nlm.nih.gov/pubmed/28357331
http://dx.doi.org/10.15698/mic2016.12.546
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author Yin, Zhangyuan
Pascual, Clarence
Klionsky, Daniel J.
author_facet Yin, Zhangyuan
Pascual, Clarence
Klionsky, Daniel J.
author_sort Yin, Zhangyuan
collection PubMed
description Macroautophagy/autophagy is an evolutionarily conserved cellular degradation process that targets cytoplasmic materials including cytosol, macromolecules and unwanted organelles. The discovery and analysis of autophagy-related (Atg) proteins have unveiled much of the machinery of autophagosome formation. Although initially autophagy was regarded as a survival response to stress, recent studies have revealed its significance in cellular and organismal homeostasis, development and immunity. Autophagic dysfunction and dysregulation are implicated in various diseases. In this review, we briefly summarize the physiological roles, molecular mechanism, regulatory network, and pathophysiological roles of autophagy.
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spelling pubmed-53489782017-03-29 Autophagy: machinery and regulation Yin, Zhangyuan Pascual, Clarence Klionsky, Daniel J. Microb Cell Microbiology Macroautophagy/autophagy is an evolutionarily conserved cellular degradation process that targets cytoplasmic materials including cytosol, macromolecules and unwanted organelles. The discovery and analysis of autophagy-related (Atg) proteins have unveiled much of the machinery of autophagosome formation. Although initially autophagy was regarded as a survival response to stress, recent studies have revealed its significance in cellular and organismal homeostasis, development and immunity. Autophagic dysfunction and dysregulation are implicated in various diseases. In this review, we briefly summarize the physiological roles, molecular mechanism, regulatory network, and pathophysiological roles of autophagy. Shared Science Publishers OG 2016-12-01 /pmc/articles/PMC5348978/ /pubmed/28357331 http://dx.doi.org/10.15698/mic2016.12.546 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Microbiology
Yin, Zhangyuan
Pascual, Clarence
Klionsky, Daniel J.
Autophagy: machinery and regulation
title Autophagy: machinery and regulation
title_full Autophagy: machinery and regulation
title_fullStr Autophagy: machinery and regulation
title_full_unstemmed Autophagy: machinery and regulation
title_short Autophagy: machinery and regulation
title_sort autophagy: machinery and regulation
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348978/
https://www.ncbi.nlm.nih.gov/pubmed/28357331
http://dx.doi.org/10.15698/mic2016.12.546
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AT pascualclarence autophagymachineryandregulation
AT klionskydanielj autophagymachineryandregulation