B cell-helping functions of gut microbial metabolites

Commensal microflora profoundly affects the host immune system. It has long been observed that commensal bacteria enhance antibody production in the host by producing antigens for B cell receptors (BCR) and ligands for Toll-like receptors (TLR). We recently reported that the microbial metabolites sh...

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Detalles Bibliográficos
Autor principal: Kim, Chang H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2016
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348987/
https://www.ncbi.nlm.nih.gov/pubmed/28357321
http://dx.doi.org/10.15698/mic2016.10.536
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author Kim, Chang H.
author_facet Kim, Chang H.
author_sort Kim, Chang H.
collection PubMed
description Commensal microflora profoundly affects the host immune system. It has long been observed that commensal bacteria enhance antibody production in the host by producing antigens for B cell receptors (BCR) and ligands for Toll-like receptors (TLR). We recently reported that the microbial metabolites short-chain fatty acids (SCFAs) regulate the metabolism and gene expression in B cells to promote antibody production (Kim et al. Gut Microbial Metabolites Fuel Host Antibody Responses. Cell Host & Microbe. 2016; 20(2):202-14). The B-cell helping function of SCFAs and its implication in the host immune system are discussed in this article.
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spelling pubmed-53489872017-03-29 B cell-helping functions of gut microbial metabolites Kim, Chang H. Microb Cell Microbiology Commensal microflora profoundly affects the host immune system. It has long been observed that commensal bacteria enhance antibody production in the host by producing antigens for B cell receptors (BCR) and ligands for Toll-like receptors (TLR). We recently reported that the microbial metabolites short-chain fatty acids (SCFAs) regulate the metabolism and gene expression in B cells to promote antibody production (Kim et al. Gut Microbial Metabolites Fuel Host Antibody Responses. Cell Host & Microbe. 2016; 20(2):202-14). The B-cell helping function of SCFAs and its implication in the host immune system are discussed in this article. Shared Science Publishers OG 2016-09-23 /pmc/articles/PMC5348987/ /pubmed/28357321 http://dx.doi.org/10.15698/mic2016.10.536 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Microbiology
Kim, Chang H.
B cell-helping functions of gut microbial metabolites
title B cell-helping functions of gut microbial metabolites
title_full B cell-helping functions of gut microbial metabolites
title_fullStr B cell-helping functions of gut microbial metabolites
title_full_unstemmed B cell-helping functions of gut microbial metabolites
title_short B cell-helping functions of gut microbial metabolites
title_sort b cell-helping functions of gut microbial metabolites
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348987/
https://www.ncbi.nlm.nih.gov/pubmed/28357321
http://dx.doi.org/10.15698/mic2016.10.536
work_keys_str_mv AT kimchangh bcellhelpingfunctionsofgutmicrobialmetabolites

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