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Survival and quality of life of patients with oral and oropharyngeal cancer at 1-year follow-up of tumor resection
OBJECTIVE: This study aimed to assess the survival and life quality evolution of patients subjected to surgical excision of oral and oropharyngeal squamous cell carcinoma. MATERIAL AND METHODS: Forty-seven patients treated at a Brazilian healthcare unit specialized in head and neck surgery between 2...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculdade de Odontologia de Bauru da Universidade de São
Paulo
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349052/ https://www.ncbi.nlm.nih.gov/pubmed/20857008 http://dx.doi.org/10.1590/S1678-77572010000300015 |
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author | BIAZEVIC, Maria Gabriela Haye ANTUNES, José Leopoldo Ferreira TOGNI, Janina de ANDRADE, Fabiana Paula de CARVALHO, Marcos Brasilino WÜNSCH-FILHO, Victor |
author_facet | BIAZEVIC, Maria Gabriela Haye ANTUNES, José Leopoldo Ferreira TOGNI, Janina de ANDRADE, Fabiana Paula de CARVALHO, Marcos Brasilino WÜNSCH-FILHO, Victor |
author_sort | BIAZEVIC, Maria Gabriela Haye |
collection | PubMed |
description | OBJECTIVE: This study aimed to assess the survival and life quality evolution of patients subjected to surgical excision of oral and oropharyngeal squamous cell carcinoma. MATERIAL AND METHODS: Forty-seven patients treated at a Brazilian healthcare unit specialized in head and neck surgery between 2006 and 2007 were enrolled in the study. The gathering of data comprised reviewing hospital files and applying the University of Washington Quality of Life (UW-QOL) questionnaire previously and 1 year after the surgery. Comparative analysis used Poisson regression to assess factors associated with survival and a paired t-test to compare preoperative and 1-year postoperative QOL ratings. RESULTS: 1 year after surgery, 7 patients were not found (dropout of the cohort); 15 had died and 25 fulfilled the UW-QOL again. The risk of death was associated with having regional metastasis previously to surgery (relative risk=2.18; 95% confidence interval=1.09-5.17) and tumor size T3 or T4 (RR=2.30; 95%CI=1.05-5.04). Survivors presented significantly (p<0.05) poorer overall and domain-specific ratings of quality of life. Chewing presented the largest reduction: from 74.0 before surgery to 34.0 one year later. Anxiety was the only domain whose average rating increased (from 36.0 to 70.7). CONCLUSIONS: The prospective assessment of survival and quality of life may contribute to anticipate interventions aimed at reducing the incidence of functional limitations in patients with oral and oropharyngeal cancer. |
format | Online Article Text |
id | pubmed-5349052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Faculdade de Odontologia de Bauru da Universidade de São
Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-53490522017-03-17 Survival and quality of life of patients with oral and oropharyngeal cancer at 1-year follow-up of tumor resection BIAZEVIC, Maria Gabriela Haye ANTUNES, José Leopoldo Ferreira TOGNI, Janina de ANDRADE, Fabiana Paula de CARVALHO, Marcos Brasilino WÜNSCH-FILHO, Victor J Appl Oral Sci Original Articles OBJECTIVE: This study aimed to assess the survival and life quality evolution of patients subjected to surgical excision of oral and oropharyngeal squamous cell carcinoma. MATERIAL AND METHODS: Forty-seven patients treated at a Brazilian healthcare unit specialized in head and neck surgery between 2006 and 2007 were enrolled in the study. The gathering of data comprised reviewing hospital files and applying the University of Washington Quality of Life (UW-QOL) questionnaire previously and 1 year after the surgery. Comparative analysis used Poisson regression to assess factors associated with survival and a paired t-test to compare preoperative and 1-year postoperative QOL ratings. RESULTS: 1 year after surgery, 7 patients were not found (dropout of the cohort); 15 had died and 25 fulfilled the UW-QOL again. The risk of death was associated with having regional metastasis previously to surgery (relative risk=2.18; 95% confidence interval=1.09-5.17) and tumor size T3 or T4 (RR=2.30; 95%CI=1.05-5.04). Survivors presented significantly (p<0.05) poorer overall and domain-specific ratings of quality of life. Chewing presented the largest reduction: from 74.0 before surgery to 34.0 one year later. Anxiety was the only domain whose average rating increased (from 36.0 to 70.7). CONCLUSIONS: The prospective assessment of survival and quality of life may contribute to anticipate interventions aimed at reducing the incidence of functional limitations in patients with oral and oropharyngeal cancer. Faculdade de Odontologia de Bauru da Universidade de São Paulo 2010 /pmc/articles/PMC5349052/ /pubmed/20857008 http://dx.doi.org/10.1590/S1678-77572010000300015 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles BIAZEVIC, Maria Gabriela Haye ANTUNES, José Leopoldo Ferreira TOGNI, Janina de ANDRADE, Fabiana Paula de CARVALHO, Marcos Brasilino WÜNSCH-FILHO, Victor Survival and quality of life of patients with oral and oropharyngeal cancer at 1-year follow-up of tumor resection |
title | Survival and quality of life of patients with oral and oropharyngeal
cancer at 1-year follow-up of tumor resection |
title_full | Survival and quality of life of patients with oral and oropharyngeal
cancer at 1-year follow-up of tumor resection |
title_fullStr | Survival and quality of life of patients with oral and oropharyngeal
cancer at 1-year follow-up of tumor resection |
title_full_unstemmed | Survival and quality of life of patients with oral and oropharyngeal
cancer at 1-year follow-up of tumor resection |
title_short | Survival and quality of life of patients with oral and oropharyngeal
cancer at 1-year follow-up of tumor resection |
title_sort | survival and quality of life of patients with oral and oropharyngeal
cancer at 1-year follow-up of tumor resection |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349052/ https://www.ncbi.nlm.nih.gov/pubmed/20857008 http://dx.doi.org/10.1590/S1678-77572010000300015 |
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