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Bactericidal antibiotics induce programmed metabolic toxicity
The misuse of antibiotics has led to the development and spread of antibiotic resistance in clinically important pathogens. These resistant infections are having a significant impact on treatment outcomes and contribute to approximately 25,000 deaths in the U.S. annually. If additional therapeutic o...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shared Science Publishers OG
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349092/ https://www.ncbi.nlm.nih.gov/pubmed/28357350 http://dx.doi.org/10.15698/mic2016.04.493 |
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author | Rowan, Aislinn D. Cabral, Damien J. Belenky, Peter |
author_facet | Rowan, Aislinn D. Cabral, Damien J. Belenky, Peter |
author_sort | Rowan, Aislinn D. |
collection | PubMed |
description | The misuse of antibiotics has led to the development and spread of antibiotic resistance in clinically important pathogens. These resistant infections are having a significant impact on treatment outcomes and contribute to approximately 25,000 deaths in the U.S. annually. If additional therapeutic options are not identified, the number of annual deaths is predicted to rise to 317,000 in North America and 10,000,000 worldwide by 2050. Identifying therapeutic methodologies that utilize our antibiotic arsenal more effectively is one potential way to extend the useful lifespan of our current antibiotics. Recent studies have indicated that modulating metabolic activity is one possible strategy that can impact the efficacy of antibiotic therapy. In this review, we will address recent advances in our knowledge about the impacts of bacterial metabolism on antibiotic effectiveness and the impacts of antibiotics on bacterial metabolism. We will particularly focus on two studies, Lobritz, et al. (PNAS, 112(27): 8173-8180) and Belenky et al. (Cell Reports, 13(5): 968-980) that together demonstrate that bactericidal antibiotics induce metabolic perturbations that are linked to and required for bactericidal antibiotic toxicity. |
format | Online Article Text |
id | pubmed-5349092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Shared Science Publishers OG |
record_format | MEDLINE/PubMed |
spelling | pubmed-53490922017-03-29 Bactericidal antibiotics induce programmed metabolic toxicity Rowan, Aislinn D. Cabral, Damien J. Belenky, Peter Microb Cell Microbiology The misuse of antibiotics has led to the development and spread of antibiotic resistance in clinically important pathogens. These resistant infections are having a significant impact on treatment outcomes and contribute to approximately 25,000 deaths in the U.S. annually. If additional therapeutic options are not identified, the number of annual deaths is predicted to rise to 317,000 in North America and 10,000,000 worldwide by 2050. Identifying therapeutic methodologies that utilize our antibiotic arsenal more effectively is one potential way to extend the useful lifespan of our current antibiotics. Recent studies have indicated that modulating metabolic activity is one possible strategy that can impact the efficacy of antibiotic therapy. In this review, we will address recent advances in our knowledge about the impacts of bacterial metabolism on antibiotic effectiveness and the impacts of antibiotics on bacterial metabolism. We will particularly focus on two studies, Lobritz, et al. (PNAS, 112(27): 8173-8180) and Belenky et al. (Cell Reports, 13(5): 968-980) that together demonstrate that bactericidal antibiotics induce metabolic perturbations that are linked to and required for bactericidal antibiotic toxicity. Shared Science Publishers OG 2016-03-09 /pmc/articles/PMC5349092/ /pubmed/28357350 http://dx.doi.org/10.15698/mic2016.04.493 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged. |
spellingShingle | Microbiology Rowan, Aislinn D. Cabral, Damien J. Belenky, Peter Bactericidal antibiotics induce programmed metabolic toxicity |
title | Bactericidal antibiotics induce programmed metabolic
toxicity |
title_full | Bactericidal antibiotics induce programmed metabolic
toxicity |
title_fullStr | Bactericidal antibiotics induce programmed metabolic
toxicity |
title_full_unstemmed | Bactericidal antibiotics induce programmed metabolic
toxicity |
title_short | Bactericidal antibiotics induce programmed metabolic
toxicity |
title_sort | bactericidal antibiotics induce programmed metabolic
toxicity |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349092/ https://www.ncbi.nlm.nih.gov/pubmed/28357350 http://dx.doi.org/10.15698/mic2016.04.493 |
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