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Bactericidal antibiotics induce programmed metabolic toxicity

The misuse of antibiotics has led to the development and spread of antibiotic resistance in clinically important pathogens. These resistant infections are having a significant impact on treatment outcomes and contribute to approximately 25,000 deaths in the U.S. annually. If additional therapeutic o...

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Autores principales: Rowan, Aislinn D., Cabral, Damien J., Belenky, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349092/
https://www.ncbi.nlm.nih.gov/pubmed/28357350
http://dx.doi.org/10.15698/mic2016.04.493
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author Rowan, Aislinn D.
Cabral, Damien J.
Belenky, Peter
author_facet Rowan, Aislinn D.
Cabral, Damien J.
Belenky, Peter
author_sort Rowan, Aislinn D.
collection PubMed
description The misuse of antibiotics has led to the development and spread of antibiotic resistance in clinically important pathogens. These resistant infections are having a significant impact on treatment outcomes and contribute to approximately 25,000 deaths in the U.S. annually. If additional therapeutic options are not identified, the number of annual deaths is predicted to rise to 317,000 in North America and 10,000,000 worldwide by 2050. Identifying therapeutic methodologies that utilize our antibiotic arsenal more effectively is one potential way to extend the useful lifespan of our current antibiotics. Recent studies have indicated that modulating metabolic activity is one possible strategy that can impact the efficacy of antibiotic therapy. In this review, we will address recent advances in our knowledge about the impacts of bacterial metabolism on antibiotic effectiveness and the impacts of antibiotics on bacterial metabolism. We will particularly focus on two studies, Lobritz, et al. (PNAS, 112(27): 8173-8180) and Belenky et al. (Cell Reports, 13(5): 968-980) that together demonstrate that bactericidal antibiotics induce metabolic perturbations that are linked to and required for bactericidal antibiotic toxicity.
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spelling pubmed-53490922017-03-29 Bactericidal antibiotics induce programmed metabolic toxicity Rowan, Aislinn D. Cabral, Damien J. Belenky, Peter Microb Cell Microbiology The misuse of antibiotics has led to the development and spread of antibiotic resistance in clinically important pathogens. These resistant infections are having a significant impact on treatment outcomes and contribute to approximately 25,000 deaths in the U.S. annually. If additional therapeutic options are not identified, the number of annual deaths is predicted to rise to 317,000 in North America and 10,000,000 worldwide by 2050. Identifying therapeutic methodologies that utilize our antibiotic arsenal more effectively is one potential way to extend the useful lifespan of our current antibiotics. Recent studies have indicated that modulating metabolic activity is one possible strategy that can impact the efficacy of antibiotic therapy. In this review, we will address recent advances in our knowledge about the impacts of bacterial metabolism on antibiotic effectiveness and the impacts of antibiotics on bacterial metabolism. We will particularly focus on two studies, Lobritz, et al. (PNAS, 112(27): 8173-8180) and Belenky et al. (Cell Reports, 13(5): 968-980) that together demonstrate that bactericidal antibiotics induce metabolic perturbations that are linked to and required for bactericidal antibiotic toxicity. Shared Science Publishers OG 2016-03-09 /pmc/articles/PMC5349092/ /pubmed/28357350 http://dx.doi.org/10.15698/mic2016.04.493 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Microbiology
Rowan, Aislinn D.
Cabral, Damien J.
Belenky, Peter
Bactericidal antibiotics induce programmed metabolic toxicity
title Bactericidal antibiotics induce programmed metabolic toxicity
title_full Bactericidal antibiotics induce programmed metabolic toxicity
title_fullStr Bactericidal antibiotics induce programmed metabolic toxicity
title_full_unstemmed Bactericidal antibiotics induce programmed metabolic toxicity
title_short Bactericidal antibiotics induce programmed metabolic toxicity
title_sort bactericidal antibiotics induce programmed metabolic toxicity
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349092/
https://www.ncbi.nlm.nih.gov/pubmed/28357350
http://dx.doi.org/10.15698/mic2016.04.493
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