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Analysis of Evolutionary Processes of Species Jump in Waterfowl Parvovirus

Waterfowl parvoviruses are classified into goose parvovirus (GPV) and Muscovy duck parvovirus (MDPV) according to their antigenic features and host preferences. A novel duck parvovirus (NDPV), identified as a new variant of GPV, is currently infecting ducks, thus causing considerable economic loss....

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Autores principales: Fan, Wentao, Sun, Zhaoyu, Shen, Tongtong, Xu, Danning, Huang, Kehe, Zhou, Jiyong, Song, Suquan, Yan, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349109/
https://www.ncbi.nlm.nih.gov/pubmed/28352261
http://dx.doi.org/10.3389/fmicb.2017.00421
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author Fan, Wentao
Sun, Zhaoyu
Shen, Tongtong
Xu, Danning
Huang, Kehe
Zhou, Jiyong
Song, Suquan
Yan, Liping
author_facet Fan, Wentao
Sun, Zhaoyu
Shen, Tongtong
Xu, Danning
Huang, Kehe
Zhou, Jiyong
Song, Suquan
Yan, Liping
author_sort Fan, Wentao
collection PubMed
description Waterfowl parvoviruses are classified into goose parvovirus (GPV) and Muscovy duck parvovirus (MDPV) according to their antigenic features and host preferences. A novel duck parvovirus (NDPV), identified as a new variant of GPV, is currently infecting ducks, thus causing considerable economic loss. This study analyzed the molecular evolution and population dynamics of the emerging parvovirus capsid gene to investigate the evolutionary processes concerning the host shift of NDPV. Two important amino acids changes (Asn-489 and Asn-650) were identified in NDPV, which may be responsible for host shift of NDPV. Phylogenetic analysis indicated that the currently circulating NDPV originated from the GPV lineage. The Bayesian Markov chain Monte Carlo tree indicated that the NDPV diverged from GPV approximately 20 years ago. Evolutionary rate analyses demonstrated that GPV evolved with 7.674 × 10(-4) substitutions/site/year, and the data for MDPV was 5.237 × 10(-4) substitutions/site/year, whereas the substitution rate in NDPV branch was 2.25 × 10(-3) substitutions/site/year. Meanwhile, viral population dynamics analysis revealed that the GPV major clade, including NDPV, grew exponentially at a rate of 1.717 year(-1). Selection pressure analysis showed that most sites are subject to strong purifying selection and no positively selected sites were found in NDPV. The unique immune-epitopes in waterfowl parvovirus were also estimated, which may be helpful for the prediction of antibody binding sites against NDPV in ducks.
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spelling pubmed-53491092017-03-28 Analysis of Evolutionary Processes of Species Jump in Waterfowl Parvovirus Fan, Wentao Sun, Zhaoyu Shen, Tongtong Xu, Danning Huang, Kehe Zhou, Jiyong Song, Suquan Yan, Liping Front Microbiol Microbiology Waterfowl parvoviruses are classified into goose parvovirus (GPV) and Muscovy duck parvovirus (MDPV) according to their antigenic features and host preferences. A novel duck parvovirus (NDPV), identified as a new variant of GPV, is currently infecting ducks, thus causing considerable economic loss. This study analyzed the molecular evolution and population dynamics of the emerging parvovirus capsid gene to investigate the evolutionary processes concerning the host shift of NDPV. Two important amino acids changes (Asn-489 and Asn-650) were identified in NDPV, which may be responsible for host shift of NDPV. Phylogenetic analysis indicated that the currently circulating NDPV originated from the GPV lineage. The Bayesian Markov chain Monte Carlo tree indicated that the NDPV diverged from GPV approximately 20 years ago. Evolutionary rate analyses demonstrated that GPV evolved with 7.674 × 10(-4) substitutions/site/year, and the data for MDPV was 5.237 × 10(-4) substitutions/site/year, whereas the substitution rate in NDPV branch was 2.25 × 10(-3) substitutions/site/year. Meanwhile, viral population dynamics analysis revealed that the GPV major clade, including NDPV, grew exponentially at a rate of 1.717 year(-1). Selection pressure analysis showed that most sites are subject to strong purifying selection and no positively selected sites were found in NDPV. The unique immune-epitopes in waterfowl parvovirus were also estimated, which may be helpful for the prediction of antibody binding sites against NDPV in ducks. Frontiers Media S.A. 2017-03-14 /pmc/articles/PMC5349109/ /pubmed/28352261 http://dx.doi.org/10.3389/fmicb.2017.00421 Text en Copyright © 2017 Fan, Sun, Shen, Xu, Huang, Zhou, Song and Yan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Fan, Wentao
Sun, Zhaoyu
Shen, Tongtong
Xu, Danning
Huang, Kehe
Zhou, Jiyong
Song, Suquan
Yan, Liping
Analysis of Evolutionary Processes of Species Jump in Waterfowl Parvovirus
title Analysis of Evolutionary Processes of Species Jump in Waterfowl Parvovirus
title_full Analysis of Evolutionary Processes of Species Jump in Waterfowl Parvovirus
title_fullStr Analysis of Evolutionary Processes of Species Jump in Waterfowl Parvovirus
title_full_unstemmed Analysis of Evolutionary Processes of Species Jump in Waterfowl Parvovirus
title_short Analysis of Evolutionary Processes of Species Jump in Waterfowl Parvovirus
title_sort analysis of evolutionary processes of species jump in waterfowl parvovirus
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349109/
https://www.ncbi.nlm.nih.gov/pubmed/28352261
http://dx.doi.org/10.3389/fmicb.2017.00421
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