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Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome

Ornithine decarboxylase (ODC), a ubiquitin-independent substrate of the proteasome, is a homodimeric protein with a rate-limiting function in polyamine biosynthesis. Polyamines regulate ODC levels by a feedback mechanism mediated by ODC antizyme (OAZ). Higher cellular polyamine levels trigger the sy...

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Detalles Bibliográficos
Autores principales:	Beenukumar, R. R., Gödderz, Daniela, Palanimurugan, R., Dohmen, R. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shared Science Publishers OG 2015
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349141/ https://www.ncbi.nlm.nih.gov/pubmed/28357293 http://dx.doi.org/10.15698/mic2015.06.206

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