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Evolutionary rewiring of bacterial regulatory networks
Bacteria have evolved complex regulatory networks that enable integration of multiple intracellular and extracellular signals to coordinate responses to environmental changes. However, our knowledge of how regulatory systems function and evolve is still relatively limited. There is often extensive h...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shared Science Publishers OG
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349173/ https://www.ncbi.nlm.nih.gov/pubmed/28357301 http://dx.doi.org/10.15698/mic2015.07.215 |
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author | Taylor, Tiffany B. Mulley, Geraldine McGuffin, Liam J. Johnson, Louise J. Brockhurst, Michael A. Arseneault, Tanya Silby, Mark W. Jackson, Robert W. |
author_facet | Taylor, Tiffany B. Mulley, Geraldine McGuffin, Liam J. Johnson, Louise J. Brockhurst, Michael A. Arseneault, Tanya Silby, Mark W. Jackson, Robert W. |
author_sort | Taylor, Tiffany B. |
collection | PubMed |
description | Bacteria have evolved complex regulatory networks that enable integration of multiple intracellular and extracellular signals to coordinate responses to environmental changes. However, our knowledge of how regulatory systems function and evolve is still relatively limited. There is often extensive homology between components of different networks, due to past cycles of gene duplication, divergence, and horizontal gene transfer, raising the possibility of cross-talk or redundancy. Consequently, evolutionary resilience is built into gene networks - homology between regulators can potentially allow rapid rescue of lost regulatory function across distant regions of the genome. In our recent study [Taylor, et al. Science (2015), 347(6225)] we find that mutations that facilitate cross-talk between pathways can contribute to gene network evolution, but that such mutations come with severe pleiotropic costs. Arising from this work are a number of questions surrounding how this phenomenon occurs. |
format | Online Article Text |
id | pubmed-5349173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Shared Science Publishers OG |
record_format | MEDLINE/PubMed |
spelling | pubmed-53491732017-03-29 Evolutionary rewiring of bacterial regulatory networks Taylor, Tiffany B. Mulley, Geraldine McGuffin, Liam J. Johnson, Louise J. Brockhurst, Michael A. Arseneault, Tanya Silby, Mark W. Jackson, Robert W. Microb Cell Microbiology Bacteria have evolved complex regulatory networks that enable integration of multiple intracellular and extracellular signals to coordinate responses to environmental changes. However, our knowledge of how regulatory systems function and evolve is still relatively limited. There is often extensive homology between components of different networks, due to past cycles of gene duplication, divergence, and horizontal gene transfer, raising the possibility of cross-talk or redundancy. Consequently, evolutionary resilience is built into gene networks - homology between regulators can potentially allow rapid rescue of lost regulatory function across distant regions of the genome. In our recent study [Taylor, et al. Science (2015), 347(6225)] we find that mutations that facilitate cross-talk between pathways can contribute to gene network evolution, but that such mutations come with severe pleiotropic costs. Arising from this work are a number of questions surrounding how this phenomenon occurs. Shared Science Publishers OG 2015-07-06 /pmc/articles/PMC5349173/ /pubmed/28357301 http://dx.doi.org/10.15698/mic2015.07.215 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged. |
spellingShingle | Microbiology Taylor, Tiffany B. Mulley, Geraldine McGuffin, Liam J. Johnson, Louise J. Brockhurst, Michael A. Arseneault, Tanya Silby, Mark W. Jackson, Robert W. Evolutionary rewiring of bacterial regulatory networks |
title | Evolutionary rewiring of bacterial regulatory networks |
title_full | Evolutionary rewiring of bacterial regulatory networks |
title_fullStr | Evolutionary rewiring of bacterial regulatory networks |
title_full_unstemmed | Evolutionary rewiring of bacterial regulatory networks |
title_short | Evolutionary rewiring of bacterial regulatory networks |
title_sort | evolutionary rewiring of bacterial regulatory networks |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349173/ https://www.ncbi.nlm.nih.gov/pubmed/28357301 http://dx.doi.org/10.15698/mic2015.07.215 |
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