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How do yeast sense mitochondrial dysfunction?

Apart from energy transformation, mitochondria play important signaling roles. In yeast, mitochondrial signaling relies on several molecular cascades. However, it is not clear how a cell detects a particular mitochondrial malfunction. The problem is that there are many possible manifestations of mit...

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Autores principales: Knorre, Dmitry A., Sokolov, Svyatoslav S., Zyrina, Anna N., Severin, Fedor F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349209/
https://www.ncbi.nlm.nih.gov/pubmed/28357322
http://dx.doi.org/10.15698/mic2016.11.537
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author Knorre, Dmitry A.
Sokolov, Svyatoslav S.
Zyrina, Anna N.
Severin, Fedor F.
author_facet Knorre, Dmitry A.
Sokolov, Svyatoslav S.
Zyrina, Anna N.
Severin, Fedor F.
author_sort Knorre, Dmitry A.
collection PubMed
description Apart from energy transformation, mitochondria play important signaling roles. In yeast, mitochondrial signaling relies on several molecular cascades. However, it is not clear how a cell detects a particular mitochondrial malfunction. The problem is that there are many possible manifestations of mitochondrial dysfunction. For example, exposure to the specific antibiotics can either decrease (inhibitors of respiratory chain) or increase (inhibitors of ATP-synthase) mitochondrial transmembrane potential. Moreover, even in the absence of the dysfunctions, a cell needs feedback from mitochondria to coordinate mitochondrial biogenesis and/or removal by mitophagy during the division cycle. To cope with the complexity, only a limited set of compounds is monitored by yeast cells to estimate mitochondrial functionality. The known examples of such compounds are ATP, reactive oxygen species, intermediates of amino acids synthesis, short peptides, Fe-S clusters and heme, and also the precursor proteins which fail to be imported by mitochondria. On one hand, the levels of these molecules depend not only on mitochondria. On the other hand, these substances are recognized by the cytosolic sensors which transmit the signals to the nucleus leading to general, as opposed to mitochondria-specific, transcriptional response. Therefore, we argue that both ways of mitochondria-to-nucleus communication in yeast are mostly (if not completely) unspecific, are mediated by the cytosolic signaling machinery and strongly depend on cellular metabolic state.
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spelling pubmed-53492092017-03-29 How do yeast sense mitochondrial dysfunction? Knorre, Dmitry A. Sokolov, Svyatoslav S. Zyrina, Anna N. Severin, Fedor F. Microb Cell Microbiology Apart from energy transformation, mitochondria play important signaling roles. In yeast, mitochondrial signaling relies on several molecular cascades. However, it is not clear how a cell detects a particular mitochondrial malfunction. The problem is that there are many possible manifestations of mitochondrial dysfunction. For example, exposure to the specific antibiotics can either decrease (inhibitors of respiratory chain) or increase (inhibitors of ATP-synthase) mitochondrial transmembrane potential. Moreover, even in the absence of the dysfunctions, a cell needs feedback from mitochondria to coordinate mitochondrial biogenesis and/or removal by mitophagy during the division cycle. To cope with the complexity, only a limited set of compounds is monitored by yeast cells to estimate mitochondrial functionality. The known examples of such compounds are ATP, reactive oxygen species, intermediates of amino acids synthesis, short peptides, Fe-S clusters and heme, and also the precursor proteins which fail to be imported by mitochondria. On one hand, the levels of these molecules depend not only on mitochondria. On the other hand, these substances are recognized by the cytosolic sensors which transmit the signals to the nucleus leading to general, as opposed to mitochondria-specific, transcriptional response. Therefore, we argue that both ways of mitochondria-to-nucleus communication in yeast are mostly (if not completely) unspecific, are mediated by the cytosolic signaling machinery and strongly depend on cellular metabolic state. Shared Science Publishers OG 2016-09-22 /pmc/articles/PMC5349209/ /pubmed/28357322 http://dx.doi.org/10.15698/mic2016.11.537 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Microbiology
Knorre, Dmitry A.
Sokolov, Svyatoslav S.
Zyrina, Anna N.
Severin, Fedor F.
How do yeast sense mitochondrial dysfunction?
title How do yeast sense mitochondrial dysfunction?
title_full How do yeast sense mitochondrial dysfunction?
title_fullStr How do yeast sense mitochondrial dysfunction?
title_full_unstemmed How do yeast sense mitochondrial dysfunction?
title_short How do yeast sense mitochondrial dysfunction?
title_sort how do yeast sense mitochondrial dysfunction?
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349209/
https://www.ncbi.nlm.nih.gov/pubmed/28357322
http://dx.doi.org/10.15698/mic2016.11.537
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