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NprR, a moonlighting quorum sensor shifting from a phosphatase activity to a transcriptional activator

Regulation of biological functions requires factors (proteins, peptides or chemicals) able to sense and translate environmental conditions or any circumstances in order to modulate the transcription of a gene, the stability of a transcript or the activity of a protein. Quorum sensing is a regulation...

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Autores principales: Perchat, Stéphane, Talagas, Antoine, Zouhir, Samira, Poncet, Sandrine, Bouillaut, Laurent, Nessler, Sylvie, Lereclus, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349214/
https://www.ncbi.nlm.nih.gov/pubmed/28357327
http://dx.doi.org/10.15698/mic2016.11.542
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author Perchat, Stéphane
Talagas, Antoine
Zouhir, Samira
Poncet, Sandrine
Bouillaut, Laurent
Nessler, Sylvie
Lereclus, Didier
author_facet Perchat, Stéphane
Talagas, Antoine
Zouhir, Samira
Poncet, Sandrine
Bouillaut, Laurent
Nessler, Sylvie
Lereclus, Didier
author_sort Perchat, Stéphane
collection PubMed
description Regulation of biological functions requires factors (proteins, peptides or chemicals) able to sense and translate environmental conditions or any circumstances in order to modulate the transcription of a gene, the stability of a transcript or the activity of a protein. Quorum sensing is a regulation mechanism connecting cell density to the physiological state of a single cell. In bacteria, quorum sensing coordinates virulence, cell fate and commitment to sporulation and other adaptation properties. The critical role of such regulatory systems was demonstrated in pathogenicity and adaptation of bacteria from the Bacillus cereus group (i.e. B. cereus and Bacillus thuringiensis). Furthermore, using insects as a model of infection, it was shown that sequential activation of several quorum sensing systems allowed bacteria to switch from a virulence state to a necrotrophic lifestyle, allowing their survival in the host cadaver, and ultimately to the commitment into sporulation. The chronological development of these physiological states is directed by quorum sensors forming the RNPP family. Among them, NprR combines two distinct functions connecting sporulation to necrotrophism in B. thuringiensis. In the absence of its cognate signaling peptide (NprX), NprR negatively controls sporulation by acting as a phosphatase. In the presence of NprX, it acts as a transcription factor regulating a set of genes involved in the survival of the bacteria in the insect cadaver.
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spelling pubmed-53492142017-03-29 NprR, a moonlighting quorum sensor shifting from a phosphatase activity to a transcriptional activator Perchat, Stéphane Talagas, Antoine Zouhir, Samira Poncet, Sandrine Bouillaut, Laurent Nessler, Sylvie Lereclus, Didier Microb Cell Microbiology Regulation of biological functions requires factors (proteins, peptides or chemicals) able to sense and translate environmental conditions or any circumstances in order to modulate the transcription of a gene, the stability of a transcript or the activity of a protein. Quorum sensing is a regulation mechanism connecting cell density to the physiological state of a single cell. In bacteria, quorum sensing coordinates virulence, cell fate and commitment to sporulation and other adaptation properties. The critical role of such regulatory systems was demonstrated in pathogenicity and adaptation of bacteria from the Bacillus cereus group (i.e. B. cereus and Bacillus thuringiensis). Furthermore, using insects as a model of infection, it was shown that sequential activation of several quorum sensing systems allowed bacteria to switch from a virulence state to a necrotrophic lifestyle, allowing their survival in the host cadaver, and ultimately to the commitment into sporulation. The chronological development of these physiological states is directed by quorum sensors forming the RNPP family. Among them, NprR combines two distinct functions connecting sporulation to necrotrophism in B. thuringiensis. In the absence of its cognate signaling peptide (NprX), NprR negatively controls sporulation by acting as a phosphatase. In the presence of NprX, it acts as a transcription factor regulating a set of genes involved in the survival of the bacteria in the insect cadaver. Shared Science Publishers OG 2016-11-04 /pmc/articles/PMC5349214/ /pubmed/28357327 http://dx.doi.org/10.15698/mic2016.11.542 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Microbiology
Perchat, Stéphane
Talagas, Antoine
Zouhir, Samira
Poncet, Sandrine
Bouillaut, Laurent
Nessler, Sylvie
Lereclus, Didier
NprR, a moonlighting quorum sensor shifting from a phosphatase activity to a transcriptional activator
title NprR, a moonlighting quorum sensor shifting from a phosphatase activity to a transcriptional activator
title_full NprR, a moonlighting quorum sensor shifting from a phosphatase activity to a transcriptional activator
title_fullStr NprR, a moonlighting quorum sensor shifting from a phosphatase activity to a transcriptional activator
title_full_unstemmed NprR, a moonlighting quorum sensor shifting from a phosphatase activity to a transcriptional activator
title_short NprR, a moonlighting quorum sensor shifting from a phosphatase activity to a transcriptional activator
title_sort nprr, a moonlighting quorum sensor shifting from a phosphatase activity to a transcriptional activator
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349214/
https://www.ncbi.nlm.nih.gov/pubmed/28357327
http://dx.doi.org/10.15698/mic2016.11.542
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