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Exogenous folates stimulate growth and budding of Candida glabrata

Folate, vitamin B9, is well recognized as being essential for cell growth. The utilization of folate is common to all cells, but the source of it may be quite different. For example, mammalian cells depend on exogenous uptake of folates, while plants and microbes can synthesize them. There has been...

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Detalles Bibliográficos
Autores principales: Porzoor, Afsaneh, Macreadie, Ian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349238/
https://www.ncbi.nlm.nih.gov/pubmed/28357288
http://dx.doi.org/10.15698/mic2015.05.202
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author Porzoor, Afsaneh
Macreadie, Ian G.
author_facet Porzoor, Afsaneh
Macreadie, Ian G.
author_sort Porzoor, Afsaneh
collection PubMed
description Folate, vitamin B9, is well recognized as being essential for cell growth. The utilization of folate is common to all cells, but the source of it may be quite different. For example, mammalian cells depend on exogenous uptake of folates, while plants and microbes can synthesize them. There has been little consideration of uptake of folate in microbial cells, and studies on the effects of folates in mammalian cells, where conditions are restricted. This study shows that exogenous folates (folic acid or folinic acid), causes Candida glabrata cells suspended in water alone to undergo two cycles of cell division and to form multiple buds. The effect was limited to cells in the stationary phase and more profound in quiescent cells. These data indicate a novel response of yeast to folates that may increase the utility of yeast as a model to study folate transport and signaling.
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spelling pubmed-53492382017-03-29 Exogenous folates stimulate growth and budding of Candida glabrata Porzoor, Afsaneh Macreadie, Ian G. Microb Cell Microbiology Folate, vitamin B9, is well recognized as being essential for cell growth. The utilization of folate is common to all cells, but the source of it may be quite different. For example, mammalian cells depend on exogenous uptake of folates, while plants and microbes can synthesize them. There has been little consideration of uptake of folate in microbial cells, and studies on the effects of folates in mammalian cells, where conditions are restricted. This study shows that exogenous folates (folic acid or folinic acid), causes Candida glabrata cells suspended in water alone to undergo two cycles of cell division and to form multiple buds. The effect was limited to cells in the stationary phase and more profound in quiescent cells. These data indicate a novel response of yeast to folates that may increase the utility of yeast as a model to study folate transport and signaling. Shared Science Publishers OG 2015-05-01 /pmc/articles/PMC5349238/ /pubmed/28357288 http://dx.doi.org/10.15698/mic2015.05.202 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Microbiology
Porzoor, Afsaneh
Macreadie, Ian G.
Exogenous folates stimulate growth and budding of Candida glabrata
title Exogenous folates stimulate growth and budding of Candida glabrata
title_full Exogenous folates stimulate growth and budding of Candida glabrata
title_fullStr Exogenous folates stimulate growth and budding of Candida glabrata
title_full_unstemmed Exogenous folates stimulate growth and budding of Candida glabrata
title_short Exogenous folates stimulate growth and budding of Candida glabrata
title_sort exogenous folates stimulate growth and budding of candida glabrata
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349238/
https://www.ncbi.nlm.nih.gov/pubmed/28357288
http://dx.doi.org/10.15698/mic2015.05.202
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