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Exogenous folates stimulate growth and budding of Candida glabrata
Folate, vitamin B9, is well recognized as being essential for cell growth. The utilization of folate is common to all cells, but the source of it may be quite different. For example, mammalian cells depend on exogenous uptake of folates, while plants and microbes can synthesize them. There has been...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shared Science Publishers OG
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349238/ https://www.ncbi.nlm.nih.gov/pubmed/28357288 http://dx.doi.org/10.15698/mic2015.05.202 |
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author | Porzoor, Afsaneh Macreadie, Ian G. |
author_facet | Porzoor, Afsaneh Macreadie, Ian G. |
author_sort | Porzoor, Afsaneh |
collection | PubMed |
description | Folate, vitamin B9, is well recognized as being essential for cell growth. The utilization of folate is common to all cells, but the source of it may be quite different. For example, mammalian cells depend on exogenous uptake of folates, while plants and microbes can synthesize them. There has been little consideration of uptake of folate in microbial cells, and studies on the effects of folates in mammalian cells, where conditions are restricted. This study shows that exogenous folates (folic acid or folinic acid), causes Candida glabrata cells suspended in water alone to undergo two cycles of cell division and to form multiple buds. The effect was limited to cells in the stationary phase and more profound in quiescent cells. These data indicate a novel response of yeast to folates that may increase the utility of yeast as a model to study folate transport and signaling. |
format | Online Article Text |
id | pubmed-5349238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Shared Science Publishers OG |
record_format | MEDLINE/PubMed |
spelling | pubmed-53492382017-03-29 Exogenous folates stimulate growth and budding of Candida glabrata Porzoor, Afsaneh Macreadie, Ian G. Microb Cell Microbiology Folate, vitamin B9, is well recognized as being essential for cell growth. The utilization of folate is common to all cells, but the source of it may be quite different. For example, mammalian cells depend on exogenous uptake of folates, while plants and microbes can synthesize them. There has been little consideration of uptake of folate in microbial cells, and studies on the effects of folates in mammalian cells, where conditions are restricted. This study shows that exogenous folates (folic acid or folinic acid), causes Candida glabrata cells suspended in water alone to undergo two cycles of cell division and to form multiple buds. The effect was limited to cells in the stationary phase and more profound in quiescent cells. These data indicate a novel response of yeast to folates that may increase the utility of yeast as a model to study folate transport and signaling. Shared Science Publishers OG 2015-05-01 /pmc/articles/PMC5349238/ /pubmed/28357288 http://dx.doi.org/10.15698/mic2015.05.202 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Microbiology Porzoor, Afsaneh Macreadie, Ian G. Exogenous folates stimulate growth and budding of Candida glabrata |
title | Exogenous folates stimulate growth and budding of Candida glabrata |
title_full | Exogenous folates stimulate growth and budding of Candida glabrata |
title_fullStr | Exogenous folates stimulate growth and budding of Candida glabrata |
title_full_unstemmed | Exogenous folates stimulate growth and budding of Candida glabrata |
title_short | Exogenous folates stimulate growth and budding of Candida glabrata |
title_sort | exogenous folates stimulate growth and budding of candida glabrata |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349238/ https://www.ncbi.nlm.nih.gov/pubmed/28357288 http://dx.doi.org/10.15698/mic2015.05.202 |
work_keys_str_mv | AT porzoorafsaneh exogenousfolatesstimulategrowthandbuddingofcandidaglabrata AT macreadieiang exogenousfolatesstimulategrowthandbuddingofcandidaglabrata |