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The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae

Acetaminophen (APAP), although considered a safe drug, is one of the major causes of acute liver failure by overdose, and therapeutic chronic use can cause serious health problems. Although the reactive APAP metabolite N-acetyl-p-benzoquinoneimine (NAPQI) is clearly linked to liver toxicity, toxicit...

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Detalles Bibliográficos
Autores principales:	Huseinovic, Angelina, van Leeuwen, Jolanda S., van Welsem, Tibor, Stulemeijer, Iris, van Leeuwen, Fred, Vermeulen, Nico P. E., Kooter, Jan M., Vos, J. Chris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349473/ https://www.ncbi.nlm.nih.gov/pubmed/28291796 http://dx.doi.org/10.1371/journal.pone.0173573

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