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Epithelial LTβR signaling controls the population size of the progenitors of medullary thymic epithelial cells in neonatal mice

The establishment of T cell central tolerance critically relies on the development and maintenance of the medullary thymic epithelial cells (mTECs). Disrupted signaling of lymphotoxin beta receptor (LTβR) results in dramatically reduced mTEC population. However, whether LTβR directly or indirectly c...

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Detalles Bibliográficos
Autores principales: Wu, Weiwei, Shi, Yaoyao, Xia, Huan, Chai, Qian, Jin, Caiwei, Ren, Boyang, Zhu, Mingzhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349570/
https://www.ncbi.nlm.nih.gov/pubmed/28290551
http://dx.doi.org/10.1038/srep44481