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Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis
BACKGROUND: We evaluated exercise-induced changes in the profile of circulating cytokines and growth factors in patients with AS. METHODS: We studied 32 consecutive asymptomatic moderate-to-severe AS patients and 32 age and sex-matched controls. Plasma levels of interleukin (IL)-6, IL-10, hepatocyte...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349660/ https://www.ncbi.nlm.nih.gov/pubmed/28291817 http://dx.doi.org/10.1371/journal.pone.0173787 |
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author | Kolasa-Trela, Renata Konieczynska, Malgorzata Bazanek, Marta Undas, Anetta |
author_facet | Kolasa-Trela, Renata Konieczynska, Malgorzata Bazanek, Marta Undas, Anetta |
author_sort | Kolasa-Trela, Renata |
collection | PubMed |
description | BACKGROUND: We evaluated exercise-induced changes in the profile of circulating cytokines and growth factors in patients with AS. METHODS: We studied 32 consecutive asymptomatic moderate-to-severe AS patients and 32 age and sex-matched controls. Plasma levels of interleukin (IL)-6, IL-10, hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and transforming growth factor (TGF)-β were measured at 4 time points, i.e. at rest, at peak bicycle exercise, one hour and 24 hours after a symptom-limited exercise. RESULTS: Exercise increased all the 5 markers in both groups (all p<0.0001). The maximum levels of all tested cytokines were higher in the AS group (all p<0.05) compared with controls. In AS patients the highest levels of VEGF, IL-6, and IL-10 were observed one hour after exercise, while in the control group at peak exercise. In both groups maximum TGF- β levels were observed one hour after exercise. HGF levels were higher at peak and one hour after test in the AS group (p = 0.0001), however the maximum value in AS was observed at peak while in controls after test. In both groups TGF-β was the only marker that remained increased 24 hours after exercise compared with the value at rest (p = 0.0001). The cytokines and growth factors showed no association with heart rate and the workload. CONCLUSION: In asymptomatic patients with moderate-to-severe AS, exercise produces a different pattern of changes in circulating cytokines and growth factors, and maximum levels of all tested cytokines were significantly higher in AS patients compared with the control group. |
format | Online Article Text |
id | pubmed-5349660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53496602017-04-06 Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis Kolasa-Trela, Renata Konieczynska, Malgorzata Bazanek, Marta Undas, Anetta PLoS One Research Article BACKGROUND: We evaluated exercise-induced changes in the profile of circulating cytokines and growth factors in patients with AS. METHODS: We studied 32 consecutive asymptomatic moderate-to-severe AS patients and 32 age and sex-matched controls. Plasma levels of interleukin (IL)-6, IL-10, hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and transforming growth factor (TGF)-β were measured at 4 time points, i.e. at rest, at peak bicycle exercise, one hour and 24 hours after a symptom-limited exercise. RESULTS: Exercise increased all the 5 markers in both groups (all p<0.0001). The maximum levels of all tested cytokines were higher in the AS group (all p<0.05) compared with controls. In AS patients the highest levels of VEGF, IL-6, and IL-10 were observed one hour after exercise, while in the control group at peak exercise. In both groups maximum TGF- β levels were observed one hour after exercise. HGF levels were higher at peak and one hour after test in the AS group (p = 0.0001), however the maximum value in AS was observed at peak while in controls after test. In both groups TGF-β was the only marker that remained increased 24 hours after exercise compared with the value at rest (p = 0.0001). The cytokines and growth factors showed no association with heart rate and the workload. CONCLUSION: In asymptomatic patients with moderate-to-severe AS, exercise produces a different pattern of changes in circulating cytokines and growth factors, and maximum levels of all tested cytokines were significantly higher in AS patients compared with the control group. Public Library of Science 2017-03-14 /pmc/articles/PMC5349660/ /pubmed/28291817 http://dx.doi.org/10.1371/journal.pone.0173787 Text en © 2017 Kolasa-Trela et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kolasa-Trela, Renata Konieczynska, Malgorzata Bazanek, Marta Undas, Anetta Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis |
title | Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis |
title_full | Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis |
title_fullStr | Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis |
title_full_unstemmed | Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis |
title_short | Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis |
title_sort | specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349660/ https://www.ncbi.nlm.nih.gov/pubmed/28291817 http://dx.doi.org/10.1371/journal.pone.0173787 |
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