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Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis

BACKGROUND: We evaluated exercise-induced changes in the profile of circulating cytokines and growth factors in patients with AS. METHODS: We studied 32 consecutive asymptomatic moderate-to-severe AS patients and 32 age and sex-matched controls. Plasma levels of interleukin (IL)-6, IL-10, hepatocyte...

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Autores principales: Kolasa-Trela, Renata, Konieczynska, Malgorzata, Bazanek, Marta, Undas, Anetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349660/
https://www.ncbi.nlm.nih.gov/pubmed/28291817
http://dx.doi.org/10.1371/journal.pone.0173787
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author Kolasa-Trela, Renata
Konieczynska, Malgorzata
Bazanek, Marta
Undas, Anetta
author_facet Kolasa-Trela, Renata
Konieczynska, Malgorzata
Bazanek, Marta
Undas, Anetta
author_sort Kolasa-Trela, Renata
collection PubMed
description BACKGROUND: We evaluated exercise-induced changes in the profile of circulating cytokines and growth factors in patients with AS. METHODS: We studied 32 consecutive asymptomatic moderate-to-severe AS patients and 32 age and sex-matched controls. Plasma levels of interleukin (IL)-6, IL-10, hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and transforming growth factor (TGF)-β were measured at 4 time points, i.e. at rest, at peak bicycle exercise, one hour and 24 hours after a symptom-limited exercise. RESULTS: Exercise increased all the 5 markers in both groups (all p<0.0001). The maximum levels of all tested cytokines were higher in the AS group (all p<0.05) compared with controls. In AS patients the highest levels of VEGF, IL-6, and IL-10 were observed one hour after exercise, while in the control group at peak exercise. In both groups maximum TGF- β levels were observed one hour after exercise. HGF levels were higher at peak and one hour after test in the AS group (p = 0.0001), however the maximum value in AS was observed at peak while in controls after test. In both groups TGF-β was the only marker that remained increased 24 hours after exercise compared with the value at rest (p = 0.0001). The cytokines and growth factors showed no association with heart rate and the workload. CONCLUSION: In asymptomatic patients with moderate-to-severe AS, exercise produces a different pattern of changes in circulating cytokines and growth factors, and maximum levels of all tested cytokines were significantly higher in AS patients compared with the control group.
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spelling pubmed-53496602017-04-06 Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis Kolasa-Trela, Renata Konieczynska, Malgorzata Bazanek, Marta Undas, Anetta PLoS One Research Article BACKGROUND: We evaluated exercise-induced changes in the profile of circulating cytokines and growth factors in patients with AS. METHODS: We studied 32 consecutive asymptomatic moderate-to-severe AS patients and 32 age and sex-matched controls. Plasma levels of interleukin (IL)-6, IL-10, hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and transforming growth factor (TGF)-β were measured at 4 time points, i.e. at rest, at peak bicycle exercise, one hour and 24 hours after a symptom-limited exercise. RESULTS: Exercise increased all the 5 markers in both groups (all p<0.0001). The maximum levels of all tested cytokines were higher in the AS group (all p<0.05) compared with controls. In AS patients the highest levels of VEGF, IL-6, and IL-10 were observed one hour after exercise, while in the control group at peak exercise. In both groups maximum TGF- β levels were observed one hour after exercise. HGF levels were higher at peak and one hour after test in the AS group (p = 0.0001), however the maximum value in AS was observed at peak while in controls after test. In both groups TGF-β was the only marker that remained increased 24 hours after exercise compared with the value at rest (p = 0.0001). The cytokines and growth factors showed no association with heart rate and the workload. CONCLUSION: In asymptomatic patients with moderate-to-severe AS, exercise produces a different pattern of changes in circulating cytokines and growth factors, and maximum levels of all tested cytokines were significantly higher in AS patients compared with the control group. Public Library of Science 2017-03-14 /pmc/articles/PMC5349660/ /pubmed/28291817 http://dx.doi.org/10.1371/journal.pone.0173787 Text en © 2017 Kolasa-Trela et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kolasa-Trela, Renata
Konieczynska, Malgorzata
Bazanek, Marta
Undas, Anetta
Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis
title Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis
title_full Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis
title_fullStr Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis
title_full_unstemmed Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis
title_short Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis
title_sort specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349660/
https://www.ncbi.nlm.nih.gov/pubmed/28291817
http://dx.doi.org/10.1371/journal.pone.0173787
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