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Identification of cerebral perfusion using arterial spin labeling in patients with seizures in acute settings

This study aimed to explore the utility of arterial spin labeling perfusion-weighted imaging (ASL-PWI) in patients with suspected seizures in acute settings. A total of 164 patients who underwent ASL-PWI for suspected seizures in acute settings (with final diagnoses of seizure [n = 129], poststroke...

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Autores principales: Yoo, Roh-Eul, Yun, Tae Jin, Yoon, Byung-Woo, Lee, Sang Kun, Lee, Soon-Tae, Kang, Koung Mi, Choi, Seung Hong, Kim, Ji-hoon, Sohn, Chul-Ho, Park, Sun-Won, Han, Moon Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349669/
https://www.ncbi.nlm.nih.gov/pubmed/28291816
http://dx.doi.org/10.1371/journal.pone.0173538
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author Yoo, Roh-Eul
Yun, Tae Jin
Yoon, Byung-Woo
Lee, Sang Kun
Lee, Soon-Tae
Kang, Koung Mi
Choi, Seung Hong
Kim, Ji-hoon
Sohn, Chul-Ho
Park, Sun-Won
Han, Moon Hee
author_facet Yoo, Roh-Eul
Yun, Tae Jin
Yoon, Byung-Woo
Lee, Sang Kun
Lee, Soon-Tae
Kang, Koung Mi
Choi, Seung Hong
Kim, Ji-hoon
Sohn, Chul-Ho
Park, Sun-Won
Han, Moon Hee
author_sort Yoo, Roh-Eul
collection PubMed
description This study aimed to explore the utility of arterial spin labeling perfusion-weighted imaging (ASL-PWI) in patients with suspected seizures in acute settings. A total of 164 patients who underwent ASL-PWI for suspected seizures in acute settings (with final diagnoses of seizure [n = 129], poststroke seizure [n = 18], and seizure mimickers [n = 17]), were included in this retrospective study. Perfusion abnormality was analyzed for: (1) pattern, (2) multifocality, and (3) atypical distribution against vascular territories. Perfusion abnormality was detected in 39% (50/129) of the seizure patients, most (94%, 47/50) being the hyperperfusion pattern. Of the patients with perfusion abnormality, multifocality or hemispheric involvement and atypical distribution against vascular territory were revealed in 46% (23/50) and 98% (49/50), respectively. In addition, seizures showed characteristic features including hyperperfusion (with or without non-territorial distribution) on ASL-PWI, thus differentiating them from poststroke seizures or seizure mimickers. In patients in whom seizure focus could be localized on both EEG and ASL-PWI, the concordance rate was 77%. The present study demonstrates that ASL-PWI can provide information regarding cerebral perfusion status in patients with seizures in acute settings and has the potential to be used as a non-invasive imaging tool to identify the cerebral perfusion in patients with seizures.
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spelling pubmed-53496692017-04-06 Identification of cerebral perfusion using arterial spin labeling in patients with seizures in acute settings Yoo, Roh-Eul Yun, Tae Jin Yoon, Byung-Woo Lee, Sang Kun Lee, Soon-Tae Kang, Koung Mi Choi, Seung Hong Kim, Ji-hoon Sohn, Chul-Ho Park, Sun-Won Han, Moon Hee PLoS One Research Article This study aimed to explore the utility of arterial spin labeling perfusion-weighted imaging (ASL-PWI) in patients with suspected seizures in acute settings. A total of 164 patients who underwent ASL-PWI for suspected seizures in acute settings (with final diagnoses of seizure [n = 129], poststroke seizure [n = 18], and seizure mimickers [n = 17]), were included in this retrospective study. Perfusion abnormality was analyzed for: (1) pattern, (2) multifocality, and (3) atypical distribution against vascular territories. Perfusion abnormality was detected in 39% (50/129) of the seizure patients, most (94%, 47/50) being the hyperperfusion pattern. Of the patients with perfusion abnormality, multifocality or hemispheric involvement and atypical distribution against vascular territory were revealed in 46% (23/50) and 98% (49/50), respectively. In addition, seizures showed characteristic features including hyperperfusion (with or without non-territorial distribution) on ASL-PWI, thus differentiating them from poststroke seizures or seizure mimickers. In patients in whom seizure focus could be localized on both EEG and ASL-PWI, the concordance rate was 77%. The present study demonstrates that ASL-PWI can provide information regarding cerebral perfusion status in patients with seizures in acute settings and has the potential to be used as a non-invasive imaging tool to identify the cerebral perfusion in patients with seizures. Public Library of Science 2017-03-14 /pmc/articles/PMC5349669/ /pubmed/28291816 http://dx.doi.org/10.1371/journal.pone.0173538 Text en © 2017 Yoo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yoo, Roh-Eul
Yun, Tae Jin
Yoon, Byung-Woo
Lee, Sang Kun
Lee, Soon-Tae
Kang, Koung Mi
Choi, Seung Hong
Kim, Ji-hoon
Sohn, Chul-Ho
Park, Sun-Won
Han, Moon Hee
Identification of cerebral perfusion using arterial spin labeling in patients with seizures in acute settings
title Identification of cerebral perfusion using arterial spin labeling in patients with seizures in acute settings
title_full Identification of cerebral perfusion using arterial spin labeling in patients with seizures in acute settings
title_fullStr Identification of cerebral perfusion using arterial spin labeling in patients with seizures in acute settings
title_full_unstemmed Identification of cerebral perfusion using arterial spin labeling in patients with seizures in acute settings
title_short Identification of cerebral perfusion using arterial spin labeling in patients with seizures in acute settings
title_sort identification of cerebral perfusion using arterial spin labeling in patients with seizures in acute settings
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349669/
https://www.ncbi.nlm.nih.gov/pubmed/28291816
http://dx.doi.org/10.1371/journal.pone.0173538
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