A cascade of multiple proteins and lipids catalyzes membrane fusion

Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into trans-complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to positi...

Descripción completa

Detalles Bibliográficos
Autores principales: Wickner, William, Rizo, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349777/
https://www.ncbi.nlm.nih.gov/pubmed/28292915
http://dx.doi.org/10.1091/mbc.E16-07-0517
Descripción
Sumario:Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into trans-complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar “wedge” domains into the bilayers, initiating the lipid rearrangements of fusion.

Ejemplares similares