Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells

Deregulation of the TAM (TYRO3, AXL, and MERTK) family of receptor tyrosine kinases (RTKs) has recently been demonstrated to predominately promote survival and chemoresistance of cancer cells. Intramembrane proteolysis mediated by presenilin/γ-secretase is known to regulate the homeostasis of some R...

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Detalles Bibliográficos
Autores principales: Lu, Yinzhong, Wan, Jun, Yang, Zhifeng, Lei, Xiling, Niu, Qi, Jiang, Lanxin, Passtoors, Willemijn M., Zang, Aiping, Fraering, Patrick C., Wu, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349800/
https://www.ncbi.nlm.nih.gov/pubmed/28034848
http://dx.doi.org/10.1096/fj.201600702R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349800/
https://www.ncbi.nlm.nih.gov/pubmed/28034848
http://dx.doi.org/10.1096/fj.201600702R

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