Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities

Werner syndrome (WS) is characterized by the premature onset of several age-associated pathologies including cancer. The protein defective in WS patients (WRN) is a helicase/exonuclease involved in DNA replication and repair. Here, we present the results of a large-scale proteome analysis that has b...

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Detalles Bibliográficos
Autores principales: Gagné, Jean-Philippe, Lachapelle, Sophie, Garand, Chantal, Tsofack, Serges P., Coulombe, Yan, Caron, Marie-Christine, Poirier, Guy G., Masson, Jean-Yves, Lebel, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349866/
https://www.ncbi.nlm.nih.gov/pubmed/27863399
http://dx.doi.org/10.18632/oncotarget.13341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349866/
https://www.ncbi.nlm.nih.gov/pubmed/27863399
http://dx.doi.org/10.18632/oncotarget.13341

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