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Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities
Werner syndrome (WS) is characterized by the premature onset of several age-associated pathologies including cancer. The protein defective in WS patients (WRN) is a helicase/exonuclease involved in DNA replication and repair. Here, we present the results of a large-scale proteome analysis that has b...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349866/ https://www.ncbi.nlm.nih.gov/pubmed/27863399 http://dx.doi.org/10.18632/oncotarget.13341 |