Cargando…

NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive malignancy characterized by heterogeneous genetic and epigenetic changes in hematopoietic progenitors that lead to abnormal self-renewal and proliferation. Despite high initial remission rates, prognosis remains poor for most AML patients, especially for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kowolik, Claudia M., Lin, Min, Xie, Jun, Overman, Larry E., Horne, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349906/ https://www.ncbi.nlm.nih.gov/pubmed/27863389 http://dx.doi.org/10.18632/oncotarget.13364

Ejemplares similares

Potent Anticancer Effects of Epidithiodiketopiperazine NT1721 in Cutaneous T Cell Lymphoma
por: Lin, Min, et al.
Publicado: (2021)

Correction: Lin et al. Potent Anticancer Effects of Epidithiodiketopiperazine NT1721 in Cutaneous T Cell Lymphoma. Cancers 2021, 13, 3367
por: Lin, Min, et al.
Publicado: (2021)

Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer
por: Kowolik, Claudia M., et al.
Publicado: (2019)

Synthesis of Potent Cytotoxic Epidithiodiketopiperazines Designed for Derivatization
por: Olsson, Chase R., et al.
Publicado: (2020)

Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer
por: Reece, Kelie M, et al.
Publicado: (2014)

CT-721, a Potent Bcr-Abl Inhibitor, Exhibits Excellent In Vitro and In Vivo Efficacy in the Treatment of Chronic Myeloid Leukemia
por: Sun, Yinghui, et al.
Publicado: (2017)

Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids
por: Kim, Justin, et al.
Publicado: (2015)

New insights into the disulfide bond formation enzymes in epidithiodiketopiperazine alkaloids
por: Liu, Huan, et al.
Publicado: (2021)

The music and history of the Baroque trumpet before 1721 /
por: Smithers, Don L., 1933-
Publicado: (1988)

Epidithiodiketopiperazines: Strain-Promoted Thiol-Mediated Cellular Uptake at the Highest Tension
por: Zong, Lili, et al.
Publicado: (2017)

Sparsomycin Exhibits Potent Antiplasmodial Activity In Vitro and In Vivo
por: Ariefta, Nanang Rudianto, et al.
Publicado: (2022)

An Eighteenth-century surgeon and apothecary: William Elmhirst (1721-1773).
por: Sigsworth, E M, et al.
Publicado: (1982)

Tricyclic analogues of epidithiodioxopiperazine alkaloids with promising in vitro and in vivo antitumor activity
por: Baumann, Marcus, et al.
Publicado: (2015)

TPGS-1000 exhibits potent anticancer activity for hepatocellular carcinoma in vitro and in vivo
por: Chen, Yidan, et al.
Publicado: (2020)

Puquitinib, a novel orally available PI3Kδ inhibitor, exhibits potent antitumor efficacy against acute myeloid leukemia
por: Xie, Chengying, et al.
Publicado: (2017)

1721. An Outbreak of Botulism Associated With Nacho Cheese Sauce From a Gas Station in California
por: Rosen, Hilary, et al.
Publicado: (2018)

Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo
por: Kamkumo, Raceline G, et al.
Publicado: (2012)

Cetylpyridinium Chloride (CPC) Exhibits Potent, Rapid Activity Against Influenza Viruses in vitro and in vivo
por: Popkin, Daniel L., et al.
Publicado: (2017)

Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia
por: Alachkar, Houda, et al.
Publicado: (2013)

Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation
por: Tang, Rui, et al.
Publicado: (2019)

L-Asparaginase Isolated from Phaseolus vulgaris Seeds Exhibited Potent Anti-Acute Lymphoblastic Leukemia Effects In-Vitro and Low Immunogenic Properties In-Vivo
por: Mohamed, Saleh A., et al.
Publicado: (2016)

Icaritin Shows Potent Anti-Leukemia Activity on Chronic Myeloid Leukemia In Vitro and In Vivo by Regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT Signalings
por: Zhu, Jian feng, et al.
Publicado: (2011)

Sanguinarine exhibits potent efficacy against cervical cancer cells through inhibiting the STAT3 pathway in vitro and in vivo
por: Zhang, Huijuan, et al.
Publicado: (2019)

(−)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo
por: Chen, Yuwen, et al.
Publicado: (2018)

Novel Sophoridine Derivatives Bearing Phosphoramide Mustard Moiety Exhibit Potent Antitumor Activities In Vitro and In Vivo
por: Li, Dongdong, et al.
Publicado: (2018)

Pectin lyase-modified red ginseng extract exhibits potent anti-glycation effects in vitro and in vivo
por: Kim, Chan-Sik, et al.
Publicado: (2017)

Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia
por: Dong, Han, et al.
Publicado: (2022)

Correction to: Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation
por: Tang, Rui, et al.
Publicado: (2021)

1721. A Transcriptional Signature of Acute Aspergillus Infection Offers High Diagnostic Accuracy Despite the Presence of Immunosuppression
por: Steinbrink, Julie M, et al.
Publicado: (2019)

P1721: PROGNOSTIC FACTORS IN PATIENTS IN THE TERMINAL PHASE OF HEMATOLOGICAL MALIGNANCIES WHO RECEIVED HOME MEDICAL CARE
por: Miyashita, N., et al.
Publicado: (2022)

Crocin Exhibits Antitumor Effects on Human Leukemia HL-60 Cells In Vitro and In Vivo
por: Sun, Yan, et al.
Publicado: (2013)

Folic Acid-Appended Hydroxypropyl-β-Cyclodextrin Exhibits Potent Antitumor Activity in Chronic Myeloid Leukemia Cells via Autophagic Cell Death
por: Hoshiko, Toshimi, et al.
Publicado: (2021)

Arzneimittel in der Therapie Friedrich Hoffmanns (1660–1742) unter besonderer Berücksichtigung der Medicina Consultatoria (1721–1723)
por: Maehle, Andreas-Holger
Publicado: (1998)

1721. BCG Vaccination Impact on Mortality: a 71 year Follow-up of a US BCG Controlled Trial
por: Costello, Varea H, et al.
Publicado: (2023)

Anti-cancer effects of ginsenoside CK on acute myeloid leukemia in vitro and in vivo
por: Hou, Yuzhu, et al.
Publicado: (2022)

NT1014, a novel biguanide, inhibits ovarian cancer growth in vitro and in vivo
por: Zhang, Lu, et al.
Publicado: (2016)

Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo
por: Serhan, Nizar, et al.
Publicado: (2020)

Potent efficacy of chlorpromazine in acute myeloid leukemia harboring KIT-D816V mutation
por: Rai, Shinya, et al.
Publicado: (2021)

Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC
por: Li, Chenying, et al.
Publicado: (2020)

Phosphodiesterase 3/4 Inhibitor Zardaverine Exhibits Potent and Selective Antitumor Activity against Hepatocellular Carcinoma Both In Vitro and In Vivo Independently of Phosphodiesterase Inhibition
por: Sun, Liping, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_9h9rsn7i9jkn6tho1vb113e323