Prognostic nutritional index as a prognostic biomarker for survival in digestive system carcinomas

The prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patients with various malignancies. We performed a meta-analysis to determine the predictive potential of PNI in digestive system cancers. Twenty-three studies with a total of 7,384 patients suffering from di...

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Detalles Bibliográficos
Autores principales: Zhao, Yang, Xu, Peng, Kang, Huafeng, Lin, Shuai, Wang, Meng, Yang, Pengtao, Dai, Cong, Liu, Xinghan, Liu, Kang, Zheng, Yi, Dai, Zhijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349936/
https://www.ncbi.nlm.nih.gov/pubmed/27888808
http://dx.doi.org/10.18632/oncotarget.13472
Descripción
Sumario:The prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patients with various malignancies. We performed a meta-analysis to determine the predictive potential of PNI in digestive system cancers. Twenty-three studies with a total of 7,384 patients suffering from digestive system carcinomas were involved in this meta-analysis. A lower PNI was significantly associated with the shorter overall survival (OS) [Hazard Ratio (HR) 1.83, 95% Confidence Interval (CI) 1.62–2.07], the poorer disease-free survival (DFS) (HR 1.85, 95% CI 1.19–2.89), and the higher rate of post-operative complications (HR 2.31, 95% CI 1.63–3.28). In conclusion, PNI was allowed to function as an efficient indicator for the prognosis of patients with digestive system carcinomas.

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