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Integrating mechanisms of response and resistance against the tubulin binding agent Eribulin in preclinical models of osteosarcoma

Osteosarcoma is the most frequently occurring bone cancer in children and adolescents. Unfortunately, treatment failures are common. Eribulin is a synthetic microtubule inhibitor that has demonstrated activity in preclinical osteosarcoma models. The effects of eribulin were evaluated in two human os...

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Detalles Bibliográficos
Autores principales: Sampson, Valerie B., Vetter, Nancy S., Zhang, Wendong, Patil, Pratima U., Mason, Robert W., George, Erika, Gorlick, Richard, Kolb, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349938/
https://www.ncbi.nlm.nih.gov/pubmed/27863409
http://dx.doi.org/10.18632/oncotarget.13358