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Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin

Tyrosyl-DNA phosphodiesterase I (TDP1) hydrolyzes the drug-stabilized 3’phospho-tyrosyl bond formed between DNA topoisomerase I (TOPO1) and DNA. TDP1-mediated hydrolysis uses a nucleophilic histidine (His(nuc)) and a general acid/base histidine (His(gab)). A Tdp1His(gab) to Arg mutant identified in...

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Detalles Bibliográficos
Autores principales:	Cuya, Selma M., Comeaux, Evan Q., Wanzeck, Keith, Yoon, Karina J., van Waardenburg, Robert C.A.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349943/ https://www.ncbi.nlm.nih.gov/pubmed/27893431 http://dx.doi.org/10.18632/oncotarget.13528

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