Lgr6+ stem cells and their progeny in mouse epidermis under regimens of exogenous skin carcinogenesis, and their absence in ensuing skin tumors

Lgr6+ cells have been identified as a novel class of proliferating (Ki67+) stem cells in mouse epidermis. We investigated their response to UV exposure in Lgr6-EGFP-Ires-CreERT2/R26R-LacZ haired and hairless mice and whether they become initiating cells of UV- or chemically induced skin tumors. UV o...

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Detalles Bibliográficos
Autores principales: van de Glind, Gerline C., Rebel, Heggert G., Out-Luiting, Jacoba J., Zoutman, Wim, Tensen, Cornelis P., de Gruijl, Frank R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349950/
https://www.ncbi.nlm.nih.gov/pubmed/27880932
http://dx.doi.org/10.18632/oncotarget.13436

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