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Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma
Human exonuclease 1 (hEXO1) is an important nuclease involved in mismatch repair system that contributes to maintain genomic stability and modulate DNA recombination. This study is aimed to explore the associations between single-nucleotide polymorphisms (SNPs) of hEXO1 and the hereditary susceptibi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349980/ https://www.ncbi.nlm.nih.gov/pubmed/27894089 http://dx.doi.org/10.18632/oncotarget.13517 |
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author | Tan, Shengkui Qin, Ruoyun Zhu, Xiaonian Tan, Chao Song, Jiale Qin, Linyuan Liu, Liu Huang, Xiong Li, Anhua Qiu, Xiaoqiang |
author_facet | Tan, Shengkui Qin, Ruoyun Zhu, Xiaonian Tan, Chao Song, Jiale Qin, Linyuan Liu, Liu Huang, Xiong Li, Anhua Qiu, Xiaoqiang |
author_sort | Tan, Shengkui |
collection | PubMed |
description | Human exonuclease 1 (hEXO1) is an important nuclease involved in mismatch repair system that contributes to maintain genomic stability and modulate DNA recombination. This study is aimed to explore the associations between single-nucleotide polymorphisms (SNPs) of hEXO1 and the hereditary susceptibility of hepatocellular carcinoma (HCC). SNPs rs1047840, rs1776148, rs3754093, rs4149867, rs4149963, and rs1776181 of hEXO1 were examined from a hospital-based case-control study including 1,196 cases (HCC patients) and 1,199 controls (non-HCC patients) in Guangxi, China. We found the rs3754093 AG genotype decreased the risk of HCC (OR=0.714, 95% CI: 0.539∼0.946). According to the results of stratification analysis, rs3754093 mutant genotype AG/GG decreased the risk of HCC with some HCC protective factors such as non-smoking, non-alcohol consumption and non-HCC family history, but also decreased the risk of HCC with HBV infection. Moreover, it was correlated to non-tumor metastasis and increased the survival of HCC patients. The results from gene-environment interaction assay indicated all hEXO1 SNPs interacted with smoking, alcohol consumption, HBV infection in pathogenesis of HCC. However, gene-gene interaction assay suggested the interaction between rs3754093 and other 5 SNPs were associated with reducing the HCC risk. These results suggest rs3754093 exhibits a protective activity to decrease the incidence risk of HCC in Guangxi, China. In addition, all SNPs in this study interacted with environment risk factors in pathogenesis of HCC. |
format | Online Article Text |
id | pubmed-5349980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53499802017-04-06 Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma Tan, Shengkui Qin, Ruoyun Zhu, Xiaonian Tan, Chao Song, Jiale Qin, Linyuan Liu, Liu Huang, Xiong Li, Anhua Qiu, Xiaoqiang Oncotarget Research Paper Human exonuclease 1 (hEXO1) is an important nuclease involved in mismatch repair system that contributes to maintain genomic stability and modulate DNA recombination. This study is aimed to explore the associations between single-nucleotide polymorphisms (SNPs) of hEXO1 and the hereditary susceptibility of hepatocellular carcinoma (HCC). SNPs rs1047840, rs1776148, rs3754093, rs4149867, rs4149963, and rs1776181 of hEXO1 were examined from a hospital-based case-control study including 1,196 cases (HCC patients) and 1,199 controls (non-HCC patients) in Guangxi, China. We found the rs3754093 AG genotype decreased the risk of HCC (OR=0.714, 95% CI: 0.539∼0.946). According to the results of stratification analysis, rs3754093 mutant genotype AG/GG decreased the risk of HCC with some HCC protective factors such as non-smoking, non-alcohol consumption and non-HCC family history, but also decreased the risk of HCC with HBV infection. Moreover, it was correlated to non-tumor metastasis and increased the survival of HCC patients. The results from gene-environment interaction assay indicated all hEXO1 SNPs interacted with smoking, alcohol consumption, HBV infection in pathogenesis of HCC. However, gene-gene interaction assay suggested the interaction between rs3754093 and other 5 SNPs were associated with reducing the HCC risk. These results suggest rs3754093 exhibits a protective activity to decrease the incidence risk of HCC in Guangxi, China. In addition, all SNPs in this study interacted with environment risk factors in pathogenesis of HCC. Impact Journals LLC 2016-11-23 /pmc/articles/PMC5349980/ /pubmed/27894089 http://dx.doi.org/10.18632/oncotarget.13517 Text en Copyright: © 2016 Tan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Tan, Shengkui Qin, Ruoyun Zhu, Xiaonian Tan, Chao Song, Jiale Qin, Linyuan Liu, Liu Huang, Xiong Li, Anhua Qiu, Xiaoqiang Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma |
title | Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma |
title_full | Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma |
title_fullStr | Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma |
title_full_unstemmed | Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma |
title_short | Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma |
title_sort | associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349980/ https://www.ncbi.nlm.nih.gov/pubmed/27894089 http://dx.doi.org/10.18632/oncotarget.13517 |
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