Triple negative breast cancer development can be selectively suppressed by sustaining an elevated level of cellular cyclic AMP through simultaneously blocking its efflux and decomposition

Triple negative breast cancer (TNBC) has the highest mortality among all breast cancer types and lack of targeted therapy is a key factor contributing to its high mortality rate. In this study, we show that 8-bromo-cAMP, a cyclic adenosine monophosphate (cAMP) analog at high concentration (> 1 mM...

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Detalles Bibliográficos
Autores principales: Wang, Wei, Li, Yue, Zhu, Jessica Y., Fang, Dongdong, Ding, Han-Fei, Dong, Zheng, Jing, Qing, Su, Shi-Bing, Huang, Shuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349984/
https://www.ncbi.nlm.nih.gov/pubmed/27901486
http://dx.doi.org/10.18632/oncotarget.13601

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