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Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases

Helicobacter pylori, one of the most frequently observed bacterium in the human intestinal flora, has been widely studied since Marshall and Warren documented a link between the presence of H. pylori in the gastrointestinal tract and gastritis and gastric ulcers. Interestingly, H. pylori has also be...

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Autores principales: Lewinska, Anna, Wnuk, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350214/
https://www.ncbi.nlm.nih.gov/pubmed/28074309
http://dx.doi.org/10.1007/s10522-017-9676-x
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author Lewinska, Anna
Wnuk, Maciej
author_facet Lewinska, Anna
Wnuk, Maciej
author_sort Lewinska, Anna
collection PubMed
description Helicobacter pylori, one of the most frequently observed bacterium in the human intestinal flora, has been widely studied since Marshall and Warren documented a link between the presence of H. pylori in the gastrointestinal tract and gastritis and gastric ulcers. Interestingly, H. pylori has also been found in several other epithelial tissues, including the eyes, ears, nose and skin that may have direct or indirect effects on host physiology and may contribute to extragastric diseases, e.g. chronic skin diseases. More recently, it has been shown that H. pylori cytotoxin CagA expression induces cellular senescence of human gastric nonpolarized epithelial cells that may lead to gastrointestinal disorders and systemic inflammation. Here, we hypothesize that also chronic skin diseases may be promoted by stress-induced premature senescence (SIPS) of skin cells, namely fibroblasts and keratinocytes, stimulated with H. pylori cytotoxins. Future studies involving cell culture models and clinical specimens are needed to verify the involvement of H. pylori in SIPS-based chronic skin diseases.
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spelling pubmed-53502142017-03-27 Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases Lewinska, Anna Wnuk, Maciej Biogerontology Opinion Article Helicobacter pylori, one of the most frequently observed bacterium in the human intestinal flora, has been widely studied since Marshall and Warren documented a link between the presence of H. pylori in the gastrointestinal tract and gastritis and gastric ulcers. Interestingly, H. pylori has also been found in several other epithelial tissues, including the eyes, ears, nose and skin that may have direct or indirect effects on host physiology and may contribute to extragastric diseases, e.g. chronic skin diseases. More recently, it has been shown that H. pylori cytotoxin CagA expression induces cellular senescence of human gastric nonpolarized epithelial cells that may lead to gastrointestinal disorders and systemic inflammation. Here, we hypothesize that also chronic skin diseases may be promoted by stress-induced premature senescence (SIPS) of skin cells, namely fibroblasts and keratinocytes, stimulated with H. pylori cytotoxins. Future studies involving cell culture models and clinical specimens are needed to verify the involvement of H. pylori in SIPS-based chronic skin diseases. Springer Netherlands 2017-01-10 2017 /pmc/articles/PMC5350214/ /pubmed/28074309 http://dx.doi.org/10.1007/s10522-017-9676-x Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Opinion Article
Lewinska, Anna
Wnuk, Maciej
Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases
title Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases
title_full Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases
title_fullStr Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases
title_full_unstemmed Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases
title_short Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases
title_sort helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases
topic Opinion Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350214/
https://www.ncbi.nlm.nih.gov/pubmed/28074309
http://dx.doi.org/10.1007/s10522-017-9676-x
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