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Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases
Helicobacter pylori, one of the most frequently observed bacterium in the human intestinal flora, has been widely studied since Marshall and Warren documented a link between the presence of H. pylori in the gastrointestinal tract and gastritis and gastric ulcers. Interestingly, H. pylori has also be...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350214/ https://www.ncbi.nlm.nih.gov/pubmed/28074309 http://dx.doi.org/10.1007/s10522-017-9676-x |
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author | Lewinska, Anna Wnuk, Maciej |
author_facet | Lewinska, Anna Wnuk, Maciej |
author_sort | Lewinska, Anna |
collection | PubMed |
description | Helicobacter pylori, one of the most frequently observed bacterium in the human intestinal flora, has been widely studied since Marshall and Warren documented a link between the presence of H. pylori in the gastrointestinal tract and gastritis and gastric ulcers. Interestingly, H. pylori has also been found in several other epithelial tissues, including the eyes, ears, nose and skin that may have direct or indirect effects on host physiology and may contribute to extragastric diseases, e.g. chronic skin diseases. More recently, it has been shown that H. pylori cytotoxin CagA expression induces cellular senescence of human gastric nonpolarized epithelial cells that may lead to gastrointestinal disorders and systemic inflammation. Here, we hypothesize that also chronic skin diseases may be promoted by stress-induced premature senescence (SIPS) of skin cells, namely fibroblasts and keratinocytes, stimulated with H. pylori cytotoxins. Future studies involving cell culture models and clinical specimens are needed to verify the involvement of H. pylori in SIPS-based chronic skin diseases. |
format | Online Article Text |
id | pubmed-5350214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-53502142017-03-27 Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases Lewinska, Anna Wnuk, Maciej Biogerontology Opinion Article Helicobacter pylori, one of the most frequently observed bacterium in the human intestinal flora, has been widely studied since Marshall and Warren documented a link between the presence of H. pylori in the gastrointestinal tract and gastritis and gastric ulcers. Interestingly, H. pylori has also been found in several other epithelial tissues, including the eyes, ears, nose and skin that may have direct or indirect effects on host physiology and may contribute to extragastric diseases, e.g. chronic skin diseases. More recently, it has been shown that H. pylori cytotoxin CagA expression induces cellular senescence of human gastric nonpolarized epithelial cells that may lead to gastrointestinal disorders and systemic inflammation. Here, we hypothesize that also chronic skin diseases may be promoted by stress-induced premature senescence (SIPS) of skin cells, namely fibroblasts and keratinocytes, stimulated with H. pylori cytotoxins. Future studies involving cell culture models and clinical specimens are needed to verify the involvement of H. pylori in SIPS-based chronic skin diseases. Springer Netherlands 2017-01-10 2017 /pmc/articles/PMC5350214/ /pubmed/28074309 http://dx.doi.org/10.1007/s10522-017-9676-x Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Opinion Article Lewinska, Anna Wnuk, Maciej Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases |
title | Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases |
title_full | Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases |
title_fullStr | Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases |
title_full_unstemmed | Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases |
title_short | Helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases |
title_sort | helicobacter pylori-induced premature senescence of extragastric cells may contribute to chronic skin diseases |
topic | Opinion Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350214/ https://www.ncbi.nlm.nih.gov/pubmed/28074309 http://dx.doi.org/10.1007/s10522-017-9676-x |
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