A short history of heme dioxygenases: rise, fall and rise again

It is well established that there are two different classes of enzymes—tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)—that catalyse the O(2)-dependent oxidation of l-tryptophan to N-formylkynurenine. But it was not always so. This perspective presents a short history of the e...

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Autor principal: Raven, Emma L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350241/
https://www.ncbi.nlm.nih.gov/pubmed/27909919
http://dx.doi.org/10.1007/s00775-016-1412-5
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author Raven, Emma L.
author_facet Raven, Emma L.
author_sort Raven, Emma L.
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description It is well established that there are two different classes of enzymes—tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)—that catalyse the O(2)-dependent oxidation of l-tryptophan to N-formylkynurenine. But it was not always so. This perspective presents a short history of the early TDO and IDO literature, the people that were involved in creating it, and the legacy that this left for the future.
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spelling pubmed-53502412017-03-27 A short history of heme dioxygenases: rise, fall and rise again Raven, Emma L. J Biol Inorg Chem Commentary It is well established that there are two different classes of enzymes—tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)—that catalyse the O(2)-dependent oxidation of l-tryptophan to N-formylkynurenine. But it was not always so. This perspective presents a short history of the early TDO and IDO literature, the people that were involved in creating it, and the legacy that this left for the future. Springer Berlin Heidelberg 2016-12-01 2017 /pmc/articles/PMC5350241/ /pubmed/27909919 http://dx.doi.org/10.1007/s00775-016-1412-5 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Commentary
Raven, Emma L.
A short history of heme dioxygenases: rise, fall and rise again
title A short history of heme dioxygenases: rise, fall and rise again
title_full A short history of heme dioxygenases: rise, fall and rise again
title_fullStr A short history of heme dioxygenases: rise, fall and rise again
title_full_unstemmed A short history of heme dioxygenases: rise, fall and rise again
title_short A short history of heme dioxygenases: rise, fall and rise again
title_sort short history of heme dioxygenases: rise, fall and rise again
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350241/
https://www.ncbi.nlm.nih.gov/pubmed/27909919
http://dx.doi.org/10.1007/s00775-016-1412-5
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