Cargando…

Small Interfering RNA Targeting Mitochondrial Calcium Uniporter Improves Cardiomyocyte Cell Viability in Hypoxia/Reoxygenation Injury by Reducing Calcium Overload

Intracellular Ca(2+) mishandling is an underlying mechanism in hypoxia/reoxygenation (H/R) injury that results in mitochondrial dysfunction and cardiomyocytes death. These events are mediated by mitochondrial Ca(2+) (mCa(2+)) overload that is facilitated by the mitochondrial calcium uniporter (MCU)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oropeza-Almazán, Yuriana, Vázquez-Garza, Eduardo, Chapoy-Villanueva, Héctor, Torre-Amione, Guillermo, García-Rivas, Gerardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350333/ https://www.ncbi.nlm.nih.gov/pubmed/28337252 http://dx.doi.org/10.1155/2017/5750897

Ejemplares similares

Changes in the Stoichiometry of Uniplex Decrease Mitochondrial Calcium Overload and Contribute to Tolerance of Cardiac Ischemia/Reperfusion Injury in Hypothyroidism
por: Chapoy-Villanueva, Héctor, et al.
Publicado: (2019)

Ischemic postconditioning and pinacidil suppress calcium overload in anoxia-reoxygenation cardiomyocytes via down-regulation of the calcium-sensing receptor
por: Zhang, Lin, et al.
Publicado: (2016)

Nanoencapsulated Quercetin Improves Cardioprotection during Hypoxia-Reoxygenation Injury through Preservation of Mitochondrial Function
por: Lozano, Omar, et al.
Publicado: (2019)

Cardioprotection Via Modulation of Calcium Homeostasis by Thiopental in Hypoxia-Reoxygenated Neonatal Rat Cardiomyocytes
por: Kim, Hyun-Soo, et al.
Publicado: (2010)

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury
por: Woods, Joshua J., et al.
Publicado: (2019)

Architecture of the Mitochondrial Calcium Uniporter
por: Oxenoid, Kirill, et al.
Publicado: (2016)

Regulatory mechanisms of mitochondrial calcium uptake by the calcium uniporter complex
por: Yamada, Akiko, et al.
Publicado: (2023)

MiR-25 Protects Cardiomyocytes against Oxidative Damage by Targeting the Mitochondrial Calcium Uniporter
por: Pan, Lei, et al.
Publicado: (2015)

Propofol Protects Hippocampal Neurons from Hypoxia-Reoxygenation Injury by Decreasing Calcineurin-Induced Calcium Overload and Activating YAP Signaling
por: Li, Xiaojun, et al.
Publicado: (2018)

The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells
por: Zhang, Linlin, et al.
Publicado: (2022)

N-n-Butyl Haloperidol Iodide Ameliorates Cardiomyocytes Hypoxia/Reoxygenation Injury by Extracellular Calcium-Dependent and -Independent Mechanisms
por: Zhang, Yanmei, et al.
Publicado: (2013)

Iron Overload and Apoptosis of HL-1 Cardiomyocytes: Effects of Calcium Channel Blockade
por: Chen, Mei-pian, et al.
Publicado: (2014)

Cryo-EM structure of the mitochondrial calcium uniporter
por: Nguyen, Nam X., et al.
Publicado: (2018)

The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders
por: Liao, Yajin, et al.
Publicado: (2017)

Calcium-sensing receptors regulate cardiomyocyte Ca(2+ )signaling via the sarcoplasmic reticulum-mitochondrion interface during hypoxia/reoxygenation
por: Lu, Fang-hao, et al.
Publicado: (2010)

TRPV1 Activation Exacerbates Hypoxia/Reoxygenation-Induced Apoptosis in H9C2 Cells via Calcium Overload and Mitochondrial Dysfunction
por: Sun, Zewei, et al.
Publicado: (2014)

Electrical recordings of the mitochondrial calcium uniporter in Xenopus oocytes
por: Tsai, Chen-Wei, et al.
Publicado: (2018)

Overexpression of Mitochondrial Calcium Uniporter Causes Neuronal Death
por: Granatiero, Veronica, et al.
Publicado: (2019)

Mechanisms of ion selectivity and throughput in the mitochondrial calcium uniporter
por: Delgado, Bryce D., et al.
Publicado: (2022)

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter (MCU)
por: Pan, Xin, et al.
Publicado: (2013)

Inhibition of Reverse-Mode Sodium-Calcium Exchanger Activity and Apoptosis by Levosimendan in Human Cardiomyocyte Progenitor Cell-Derived Cardiomyocytes after Anoxia and Reoxygenation
por: Li, Ping-Chun, et al.
Publicado: (2014)

Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis
por: Marmolejo-Garza, Alejandro, et al.
Publicado: (2023)

Calcium Overload and Mitochondrial Metabolism
por: Walkon, Lauren L., et al.
Publicado: (2022)

Iron Overload, Oxidative Stress and Calcium Mishandling in Cardiomyocytes: Role of the Mitochondrial Permeability Transition Pore
por: Gordan, Richard, et al.
Publicado: (2020)

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals
por: Qiu, Jing, et al.
Publicado: (2013)

Resveratrol Prevents Right Ventricle Dysfunction, Calcium Mishandling, and Energetic Failure via SIRT3 Stimulation in Pulmonary Arterial Hypertension
por: Bernal-Ramírez, Judith, et al.
Publicado: (2021)

Activity of the mitochondrial calcium uniporter varies greatly between tissues
por: Fieni, Francesca, et al.
Publicado: (2012)

An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter
por: Ghosh, Sagnika, et al.
Publicado: (2020)

Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia
por: Langenbacher, Adam D., et al.
Publicado: (2020)

RYR2-ryanodinopathies: from calcium overload to calcium deficiency
por: Steinberg, Christian, et al.
Publicado: (2023)

Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes
por: Lozano, Omar, et al.
Publicado: (2020)

Dexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulating FKBP12.6/RyR2 signaling
por: Yuan, Mei, et al.
Publicado: (2019)

Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25
por: Marchi, Saverio, et al.
Publicado: (2013)

Mitochondrial calcium uniporter, MiRNA and cancer: Live and let die
por: Marchi, Saverio, et al.
Publicado: (2013)

Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter
por: Huang, Guozhong, et al.
Publicado: (2013)

Structure and function of the N‐terminal domain of the human mitochondrial calcium uniporter
por: Lee, Youngjin, et al.
Publicado: (2015)

The calcium uniporter regulates the permeability transition pore in isolated cortical mitochondria★
por: Yu, Ning, et al.
Publicado: (2012)

Structure, Activity Regulation, and Role of the Mitochondrial Calcium Uniporter in Health and Disease
por: Mammucari, Cristina, et al.
Publicado: (2017)

DS16570511 is a small-molecule inhibitor of the mitochondrial calcium uniporter
por: Kon, Naohiro, et al.
Publicado: (2017)

Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics
por: Flicker, Daniel, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gh5a922gqeah8lgoj3510ev02c