The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein

Phosphatase and tensin homologue (PTEN) protein levels are critical for tumor suppression. However, the search for a recurrent cancer-associated gene alteration that causes PTEN degradation has remained futile. In this study, we show that Importin-11 (Ipo11) is a transport receptor for PTEN that is...

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Detalles Bibliográficos
Autores principales: Chen, Muhan, Nowak, Dawid G., Narula, Navneet, Robinson, Brian, Watrud, Kaitlin, Ambrico, Alexandra, Herzka, Tali M., Zeeman, Martha E., Minderer, Matthias, Zheng, Wu, Ebbesen, Saya H., Plafker, Kendra S., Stahlhut, Carlos, Wang, Victoria M.Y., Wills, Lorna, Nasar, Abu, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Wilkinson, John E., Powers, Scott, Sordella, Raffaella, Altorki, Nasser K., Mittal, Vivek, Stiles, Brendon M., Plafker, Scott M., Trotman, Lloyd C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350510/
https://www.ncbi.nlm.nih.gov/pubmed/28193700
http://dx.doi.org/10.1083/jcb.201604025

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